Anti-CD36 Antibody Prodrug, Protease Activated (VS-1025-YC176)
CAT#: VS-1025-YC176
The Anti-CD36 Antibody Prodrug, Protease Activated (VS-1025-YC176) is an antibody prodrug comprised of a recombinant human antibody targeting human CD36, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to CD36 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to CD36 effectively. CD36 is a fatty acid translocase whose high expression is strongly associated with the metastasis of certain tumors, particularly oral squamous cell carcinoma and melanoma. It promotes the uptake of fatty acids, supporting the enhanced lipid metabolism required for aggressive tumor growth.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2018/1770_D7_3_selected.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2018/7436_A_7_3.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (ASC diff, HEL)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135218-CD36
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human CD36
- Target
- CD36
- Species Reactivity
- Human
- Isotype
- Chimeric (rabbit/human) IgG1
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene.
- Alternative Names
- BDPLT10; CHDS7; FAT; GP3B; GP4; GPIV; PASIV; SCARB3
- Gene ID
- 948
- UniProt ID
- P16671
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Related Signaling Pathways
Insulin Signaling Pathway
Downloadable Resources
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Datasheet
MSDS
COA
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