Human Anti-CD36 scFv-Fc Chimera (VS-0325-FY39)

CAT#: VS-0325-FY39

The anti-CD36 scFv-Fc antibody targets CD36, a scavenger receptor involved in lipid metabolism and immune responses. It is designed to modulate CD36 function, which may have therapeutic implications in atherosclerosis and other lipid-related disorders.

Gene Expression
Figure 1 IF staining of human cell line HEL Figure 2 Colon Figure 3 RNA cell line category: Group enriched (ASC diff, HEL)

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG1, scFv-Fc
  • Specificity
  • It was able to specifically bind to both human CD36 and mouse CD36.
  • Species Reactivity
  • Human, Mouse
  • Applications
  • ELISA, Inhibition, Flow Cytometry
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Target

  • Alternative Names
  • CD36 Molecule; CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor); CD36 Molecule (Thrombospondin Receptor); Leukocyte Differentiation Antigen CD36; Platelet Glycoprotein IV; Fatty Acid Translocase; Glycoprotein IIIb; PAS IV; GPIIIB; GP3B; GPIV; FAT; GP4
  • Long Name
  • CD36 Molecule
  • Sequence Similarities
  • Belongs to the CD36 family.
  • Cellular Localization
  • Cell membrane; Membrane raft; Golgi apparatus; Apical cell membrane
  • Post Translation Modifications
  • N-glycosylated and O-glycosylated with a ratio of 2:1.
    Palmitoylated by ZDHHC5.
    Palmitoylation is required for proper localization at the plasma membrane.
    Ubiquitinated at Lys-469 and Lys-472.
    Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome.
    Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids.
    Glycosylation at Asn79, Asn102, Asn134, Asn205, Asn220, Asn163, Asn235, Asn247, Asn321, and Asn417
    Ubiquitination at Lys469 and Lys472
    Modification sites at PhosphoSitePlus
    Glycosylation from GlyConnect CD36_HUMAN (1611)
    Glycosylation from GlyGen
  • Function
  • CD36 is a multifunctional membrane protein involved in various biological processes, including fatty acid uptake, thrombospondin binding, and cellular adhesion. It plays a role in lipid metabolism, angiogenesis, and inflammation, and is implicated in diseases such as atherosclerosis and diabetes.
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

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COA

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Isotype Control

Secondary Antibody

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