Mouse Anti-CD79A Recombinant Antibody (clone HM47) (CAT#: VS3-CJ605)

• Immunogen
• Native purified human CD79a

• Host Species
• Mouse

• Type
• Mouse IgG1, κ

• Specificity
• Human CD79A

• Species Reactivity
• Human

• Clone
• HM47

• Applications
• IF, FC

• Conjugate
• Unconjugated

• Purification
• Affinity chromatography

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• PBS, pH 7.3.

• Preservative
• 0.02% Sodium Azide

• Storage
• Store at 4°C for one year. Do not freeze.

• Shipping
• Shipped at 4°C

• Application Notes
• This antibody has been tested for use in Immunofluorescence, Flow Cytometry.

• Alternative Names
• IGA; MB1; MB-1; IGAlpha

• Gene ID
• 973

• UniProt ID
• P11912

• Cellular Localization
• Cell membrane, Membrane

• Post Translation Modifications
• Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.
  Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).

• Protein Refseq
• NP_001774.1; NP_067612.1

• Function
• Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Secondary Antibody

• 2RD-A1460-YJ
• Goat Anti-Mouse IgG1 Secondary antibody

• 2RD-A1562-YJ
• Rabbit Anti-Mouse IgG1 Secondary antibody (Clone RM106)

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

• FAMAB-1083CQ
• Human Anti-CD79A Recombinant Antibody (clone HM47)

• FAMAB-1083CQ-mRNA
• Human Anti-CD79A Antibody (clone HM47), mRNA