Mouse Anti-CD79A Recombinant Antibody (clone HM47)
CAT#: VS3-CJ605
This product is a mouse antibody that recognizes human CD79A.
Gene Expression
Normal Tissue
Figure 1 Colon
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19/247_A_7_3.jpg
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Specifications
- Immunogen
- Native purified human CD79a
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human CD79A
- Species Reactivity
- Human
- Clone
- HM47
- Applications
- IF, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS, pH 7.3.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C for one year. Do not freeze.
- Shipping
- Shipped at 4°C
Applications
- Application Notes
- This antibody has been tested for use in Immunofluorescence, Flow Cytometry.
Target
- Alternative Names
- IGA; MB1; MB-1; IGAlpha
- Gene ID
- 973
- UniProt ID
- P11912
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.
Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).
- Protein Refseq
- NP_001774.1; NP_067612.1
- Function
- Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
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Related Signaling Pathways
BCR Signaling Pathway
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "Clone HM47"
- CAT
- Product Name
See other products for "CD79A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1069z | Mouse Anti-CD79A Recombinant Antibody (clone 20D6) | WB, IP, IF, IHC, ELISA, FuncS | Mouse IgG1, κ |
| FAMAB-1082CQ | Human Anti-CD79A Recombinant Antibody (clone JCB117) | WB, IF, IHC | Human IgG1 |
| FAMAB-1083CQ | Human Anti-CD79A Recombinant Antibody (clone HM47) | IP, WB, IHC | Human IgG1 |
| FAMAB-1084CQ | Human Anti-CD79A Recombinant Antibody (clone HM57) | IP, IF, IHC | Human IgG1 |
| VS3-FY317 | Recombinant Mouse Anti-CD79A Antibody (clone 10A10-10C3-1H9) | IHC-P | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0654MZ | Chicken Anti-Human IgA Polyclonal IgY | N/A | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0580 | Hi-Affi™ Rabbit Anti-CD79A Recombinant Antibody (clone DS580AB) | FC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0458-WJ-F(E) | Mouse Anti-CD79A Recombinant Antibody; Fab Fragment (HPAB-0458-WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0458-WJ-S(P) | Mouse Anti-CD79A Recombinant Antibody; scFv Fragment (HPAB-0458-WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY111 | Mouse Anti-NHP CD79A Recombinant Antibody (clone HM57) | WB, IHC, IF, FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY374 | Anti-CD79a Immunohistochemistry Kit | IHC | |
| VS-0525-XY1220 | Anti-Mouse CD79A Immunohistochemistry Kit | IHC | |
| VS-0525-XY1219 | Anti-Human CD79A Immunohistochemistry Kit | IHC | |
| VS-0525-XY1221 | Anti-Porcine CD79A Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC727 | Recombinant Anti-CD79A Vesicular Antibody, EV Displayed (VS-0425-YC727) | ELISA, FC, Cell-uptake |
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