Anti-CDH11 Antibody Prodrug, Protease Activated (VS-1025-YC118)
CAT#: VS-1025-YC118
The Anti-CDH11 Antibody Prodrug, Protease Activated (VS-1025-YC118) is an antibody prodrug comprised of a recombinant human antibody targeting human CDH11, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to CDH11 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to CDH11 effectively. CDH11 (Cadherin 11) is a cell adhesion molecule whose ectopic expression in cancers, such as prostate and breast cancer, promotes invasion and metastasis. It drives cell migration by initiating a partial epithelial-mesenchymal transition (EMT)-like process and facilitating adhesion to cells within the bone microenvironment.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13072/32893_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13072/32893_A_8_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli
Staining:High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13072/32893_A_7_5.jpg
Normal Tissue
Figure 4 Breast
Glandular cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Myoepithelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13072/32893_B_2_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, HSkMC, PC-3, U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140937-CDH11
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human CDH11
- Target
- CDH11
- Species Reactivity
- Human
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.
- Alternative Names
- CDH11; cadherin 11, type 2, OB-cadherin (osteoblast); OB; CAD11; CDHOB; OSF-4
- Gene ID
- 1009
- UniProt ID
- P55287
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Datasheet
MSDS
COA
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