CytoStream™ Rabbit Anti-CDK5 Recombinant Antibody (VS13-YC199)
CAT#: VS13-YC199
The CytoStream™ Rabbit Anti-CDK5 Recombinant Antibody is specific for human, mouse and rat CDK5. CDK5 participates in neurological development and disorders, exemplifying roles in kinase-related signaling pathways. The anti-CDK5 antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64535/1202_C5_1_selected.jpg
Normal Tissue
Figure 2 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8909/22984_A_6_6.jpg
Normal Tissue
Figure 3 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8909/22984_A_8_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8909/22984_B_8_5.jpg
Normal Tissue
Figure 5 Caudate
Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8909/22984_B_9_7.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8909/22984_A_7_3.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164885-CDK5
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Specifications
- Immunogen
- Recombinant human Cdk5, aa 243-292.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CDK5
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC-P, FC, IP
- Conjugate
- NONE
- Related Disease
- Lissencephaly 7 With Cerebellar Hypoplasia and Lissencephaly
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500
Immunohistochemistry-paraffin (IHC-P): 1/50-1/400
Flow cytometry (FC): 1/50
Target
- Alternative Names
- Cyclin Dependent Kinase 5; Serine/Threonine-Protein Kinase PSSALRE; Tau Protein Kinase II Catalytic Subunit; Cell Division Protein Kinase 5; TPKII Catalytic Subunit; Cyclin-Dependent-Like Kinase 5; Protein Kinase CDK5 Splicing;
- Gene ID
- 1020
- UniProt ID
- Q00535
- Long Name
- Cyclin Dependent Kinase 5
- Cellular Localization
- Cell membrane; Cell projection; Cytoplasm; Nucleus; Synapse
- Protein Refseq
- NP_004926.1; NP_001157882.1
- Function
- Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "CDK5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0162CT | Recombinant Mouse anti-Human CDK5 Monoclonal antibody (5F5) | ELISA, FC, ICC, IF, IHC-P, WB | |
| VS3-QX217 | Mouse Anti-CDK5 Recombinant Antibody (clone 3C9-E10-E4) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-WK833 | Mouse Anti-CDK5 Recombinant Antibody (VS3-WK833) | WB | Mouse IgG1, κ |
| VS3-WK834 | Rabbit Anti-CDK5 Recombinant Antibody (VS3-WK834) | WB, IHC, IP, FC | Rabbit IgG |
| VS3-XY3307 | Rabbit Anti-CDK5 Recombinant Antibody (clone R08-9I3) | WB, IHC-P, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0631 | Hi-Affi™ Rabbit Anti-CDK5 Recombinant Antibody (clone DS631AB) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY118 | Mouse Anti-NHP CDK5 Recombinant Antibody (clone 4E4) | WB, IHC, IF, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY405 | Anti-CDK5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1318 | Anti-Human CDK5 Immunohistochemistry Kit | IHC |
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