Anti-CDK5 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs’ state-of-the-art recombinant antibody technology platform is here to help you with your neuroscience research. CDK5 is a non-canonical, proline-directed serine/threonine kinase and plays critical roles in neuronal development and physiology, as well as being a major driver of neurofibrillary tangles in Alzheimer’s disease. Our high quality antibodies can serve as key tools for studying its unique regulation and the neurodegeneration it causes.

CDK5: A Key Kinase in Neuronal Function and Alzheimer's Disease

CDK5 is a highly atypical CDK kinase. Structurally and mechanistically related to the cell cycle CDKs, CDK5 activity is nearly undetectable in non-neuronal proliferating cells. Instead, CDK5 is constitutively active in post-mitotic neurons, and its activity is regulated not by cyclins but by its unique activators, p35 and p39. CDK5 is critical for neuronal migration, differentiation, and synaptic plasticity. During pathological stress (amyloid-beta toxicity, for example), the p35 activator becomes cleaved into the hyperactive p25 fragment, resulting in aberrant, over-active CDK5 signaling and the pathological hyperphosphorylation of Tau protein, which in turn aggregates to form the neurofibrillary tangles that are a hallmark of Alzheimer’s disease.

Alternative Names

Cyclin Dependent Kinase 5; Serine/Threonine-Protein Kinase PSSALRE; Tau Protein Kinase II Catalytic Subunit; Cell Division Protein Kinase 5

Background

CDK5 (Cyclin Dependent Kinase 5) is a Protein Coding gene. Diseases associated with CDK5 include Lissencephaly 7 With Cerebellar Hypoplasia and Lissencephaly. Among its related pathways are Development Slit-Robo signaling and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK3.

Anti-CDK5 rAb Products

Creative Biolabs’ anti-CDK5 recombinant antibodies are designed and screened for the highest levels of specificity and performance. We have antibodies that detect total CDK5, as well as antibodies that can detect the hyperactive p25 activator fragment. Optimized for use in applications such as IHC on brain tissue for neurofibrillary pathology or Western Blot, our rAbs are premier products for neurodegenerative research.

Table 1. Featured anti-CDK5 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs lives by one core tenet: Scientific Integrity. The development of our anti-CDK5 recombinant antibodies is done under a robust quality assurance platform. Every lot of antibody is tested for purity, specificity, and validated performance in neurodegeneration models.

Customer Reviews

rAb Production

Creative Biolabs has unique expertise in recombinant antibody technology, which we leverage to support the highly specialized field of neuroscience. Our anti-CDK5 recombinant antibodies are rigorously developed and screened to provide the highest affinity recognition of this important regulatory kinase.

Featured Anti-CDK5 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-CDK5 recombinant antibody production.

Fig.4 Gram-scale anti-CDK5 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to facilitating research breakthroughs by providing flexible and affordable antibody solutions. Our anti-CDK5 recombinant antibodies are available in a variety of modalities to best meet the needs of researchers around the globe looking to study this important enzyme.

Fig.5 Full-length anti-CDK5 recombinant antibody production and modalities.

Your best choice for neuroscience research: Creative Biolabs’ high-quality anti-CDK5 recombinant antibodies. We have the validation and unique specificity to help you understand this critical enzyme’s role in Alzheimer’s disease. Contact our scientific team today.