Rabbit Anti-CELF1 Recombinant Antibody (clone R03-0G7) (CAT#: VS3-FY1992)
This is a rabbit recombinant monoclonal antibody, which detects human CELF1. It cross-reacts with rat. It is suitable for use in a variety of assays, including WB, IHC-F, IHC-P, ICC/IF, IP. To validate the QC result of the antibody, we recommend a dilution for the antibody by western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100), immunofluorescence (dilution 1/50-1/200), immunoprecipitation (dilution 1/20).
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WB
Figure 1 Anti-CELF1 Antibody (VS3-FY1992) in WB.
The CUGBP1 expression in rat brain lysates were detected using the anti-CUGBP1 by western blot assay.
WB
Figure 2 Anti-CELF1 Antibody (VS3-FY1992) in WB.
The CUGBP1 expression in Hela, Ramos lysates were detected using the anti-CUGBP1 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human CUG-BP1
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat CELF1
- Species Reactivity
- Human, Rat
- Clone
- R03-0G7
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 52 kDa, while the observed molecular weight stands at 52 kDa.
- Related Disease
- Myotonic Dystrophy and Myotonic Dystrophy 1
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunofluorescence: 1/50-1/200
Immunoprecipitation: 1/20
Target
- Alternative Names
- CUGBP Elav-Like Family Member 1; Embryo Deadenylation Element-Binding Protein Homolog; Nuclear Polyadenylated RNA-Binding Protein, 50-KD; 50 KDa Nuclear Polyadenylated RNA-Binding Protein; Embryo Deadenylation Element Binding Protein; CUG Triplet Repeat RNA-Binding Protein 1; CUG-BP- And ETR-3-Like Factor 1; RNA-Binding Protein BRUNOL-2; Deadenylation Factor CUG-BP; CUG RNA-Binding Protein; Bruno-Like Protein 2; EDEN-BP Homolog; Bruno-Like 2; BRUNOL2
- Gene ID
- 10658
- UniProt ID
- Q92879
- Sequence Similarities
- Belongs to the CELF/BRUNOL family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Phosphorylated.
Its phosphorylation status increases in senescent cells.
(Q92879-CELF1_HUMAN)
Ubiquitination at Lys166 (NX_Q92879 [NX_Q92879-1])
Modification sites at PhosphoSitePlus (Q92879)
Glycosylation from GlyGen (Q92879) 7 sites, 1 O-linked glycan (7 sites)
- Protein Refseq
- XP_011518159.1; XP_016872590.1; XP_047282223.1; XP_047282224.1; XP_047282225.1
- Function
- Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2380CT | Recombinant Mouse anti-Human CELF1 Monoclonal antibody (3B1) | WB, IP, ICC | |
| MRO-0351-CN | Mouse Anti-CELF1 Recombinant Antibody (clone 7A1) | IHC, WB | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
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