CytoStream™ Rabbit Anti-CELF1 Recombinant Antibody (VS13-YC208) (CAT#: VS13-YC208)

• Immunogen
• Recombinant human CELF1.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat CELF1

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, IHC-P, ICC, IF, IP, FC

• Conjugate
• NONE

• Related Disease
• Myotonic Dystrophy and Myotonic Dystrophy

• Clonality
• Monoclonal

• Purification
• Affinity Chromatography purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS (pH 7.4) containing 150 mM NaCl and 50% Glycerol.

• Preservative
• 0.02% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/500-1/1000
  Immunohistochemistry (IHC): 1/50-1/100
  Immunofluorescence (IF): 1/50-1/200
  Immunoprecipitation (IP): 1/50
  Flow cytometry (FC): 1/50-1/100

• Alternative Names
• CUGBP Elav-Like Family Member 1; Embryo Deadenylation Element-Binding Protein Homolog; Nuclear Polyadenylated RNA-Binding Protein, 50-KD; 50 KDa Nuclear Polyadenylated RNA-Binding Protein; Embryo Deadenylation Element Binding Protein; CUG Triplet Repeat RNA-Binding Protein 1; CUG-BP- And ETR-3-Like Factor 1; RNA-Binding Protein BRUNOL-2; Deadenylation Factor CUG-BP; CUG RNA-Binding Protein; Bruno-Like Protein 2; EDEN-BP Homolog; Bruno-Like 2; BRUNOL2;

• Gene ID
• 10658

• UniProt ID
• Q92879

• Long Name
• CUGBP Elav-Like Family Member 1

• Sequence Similarities
• Belongs to the CELF/BRUNOL family.

• Cellular Localization
• Cytoplasm; Nucleus

• Protein Refseq
• XP_011518159.1; XP_016872590.1; XP_047282223.1; XP_047282224.1; XP_047282225.1

• Function
• Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity).

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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