Rabbit Anti-CHEK1 Recombinant Antibody (clone R02-1D6)
CAT#: VS3-XY3314
It is a recombinant rabbit antibody that specifically recognizes human CHEK1 (Checkpoint kinase 1), which regulates the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones. It also has cross-reactivity against mouse or rat CHEK1. It has been reported for use in Western Blot, Immunoprecipitation, Immunocytochemistry or Immunofluorescence.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44364/if_selected.jpg
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CHEK1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R02-1D6
- Applications
- WB, ICC, IF, IP
- Related Disease
- Oocyte/Zygote/Embryo Maturation Arrest 21; Ataxia-Telangiectasia
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
IP: 1/20
Target
- Alternative Names
- CHK1; OZEMA21
- Gene ID
- 1111
- UniProt ID
- O14757
- Long Name
- Checkpoint kinase 1
- Cellular Localization
- Chromosome, Cytoplasm, Cytoskeleton, Nucleus
- Post Translation Modifications
- Ubiquitination at Lys132, Lys180, Lys244, Lys313, and Lys436 (NX_O14757 [NX_O14757-1])
Modification sites at PhosphoSitePlus (O14757)
Glycosylation from GlyGen (O14757) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011540862.1; XP_024304105.1
- Function
- May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T].
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CHEK1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0005CT | Recombinant Mouse anti-Human CHEK1 Monoclonal antibody (7G6) | WB | |
| ZG-0016U | Rabbit Anti-CHEK1 Recombinant Antibody (clone 2F2) | ELISA, WB, IHC, IF | Rabbit IgG |
| VS3-XY498 | Mouse Anti-CHEK1 Recombinant Antibody (clone 2G1D5) | ELISA, WB | Mouse IgG1 |
| VS3-WK2092 | Rabbit Anti-CHEK1 (pS280) Recombinant Antibody (clone R32-4D-1) | WB | Rabbit IgG |
| VS3-WK2139 | Rabbit Anti-CHEK1 (pS296) Recombinant Antibody (clone R02-4Z6) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0688 | Hi-Affi™ Rabbit Anti-CHEK1 Recombinant Antibody (clone DS688AB) | IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY120 | Mouse Anti-NHP CHEK1 Recombinant Antibody (clone T.59.2) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY38 | Mouse Anti-CHEK1 scFv-Fc Chimera (VS-0125-FY38) | FC | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC216 | CytoStream™ Rabbit Anti-CHEK1 Recombinant Antibody (VS13-YC216) | WB, ICC, IF, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1428 | Anti-CHEK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1429 | Anti-Mouse CHEK1 Immunohistochemistry Kit | IHC |
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