AibGenesis™ Rabbit Anti-CSNK1A1 Recombinant Antibody (AibG-Rb-CS352)
CAT#: VS-0426-FY352
Developed through our AI-powered antibody discovery platform, this Rabbit IgG targets Casein Kinase 1 alpha (CSNK1A1). Validated for WB across multiple species, it delivers high specificity for monitoring the serine/threonine kinase activity essential for Wnt signaling, circadian rhythms, and DNA damage response.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/51334/987_E11_2_selected.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16680/45566_A_7_3.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16680/45566_A_6_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16680/45566_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113712-CSNK1A1
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CSNK1A1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-CS352
- Applications
- Western Blot
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Enterobiasis and Alzheimer's Disease
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS, 0.05% Protective protein, 50% Glycerol
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:1000-1:2000)
Target
- Alternative Names
- CK1; CK1A; CKI alpha; CKIa; Csnk1a1; HLCDGP1; CK I alpha
- UniProt ID
- P48729
- Long Name
- Casein Kinase 1 Alpha 1
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cytoplasm, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Chromosome, centromere, kinetochore, Nucleus speckle, Cytoplasm, cytoskeleton, cilium basal body, Cytoplasm, cytoskeleton, spindle
- Post Translation Modifications
- Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation. (P48729-KC1A_HUMAN)
Ubiquitination at Lys8, Lys62, Lys65, Lys138, Lys225, and Lys304 (NX_P48729 [NX_P48729-1])
Modification sites at PhosphoSitePlus (P48729)
Glycosylation from GlyGen (P48729) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001020276.1; NP_001258670.1; NP_001258671.1; NP_001883.4
- Function
- May play a role in segregating chromosomes during mitosis (PubMed:1409656).
May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor.
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Related Diseases
Endometrial Cancer
Throid Cancer
Related Signaling Pathways
p53 Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CSNK1A1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0322CT | Recombinant Mouse anti-Human CSNK1A1 Monoclonal antibody (BU3F3) | ELISA, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0798MZ | Chicken Anti-CK1 alpha Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0835 | Hi-Affi™ Rabbit Anti-CSNK1A1 Recombinant Antibody (clone DS835AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0364F | Mouse Anti-CSNK1A1 Recombinant Antibody (ZG-0364F) | WB, IHC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY416 | Recombinant Rabbit Anti-CSNK1A1 Antibody (clone R05-6C6) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS7-HM781 | Mouse Anti-CSNK1A1 Recombinant Antibody (clone CBL184HM) | WB, IHC-p, IF, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY560 | Anti-CSNK1A1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1718 | Anti-Mouse CSNK1A1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1717 | Anti-Human CSNK1A1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS14-YC305 | AibGenesis™ Rabbit Anti-CSNK1A1 Recombinant Antibody (AibG-Rb-SN105) | WB | Rabbit IgG |
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