AibGenesis™ Rabbit Anti-CUL4B Recombinant Antibody (AibG-Rb-UL113)
CAT#: VS14-YC313
Designed for high-performance research, the AI-derived anti-CUL4B mAb (AibG-Rb-UL113) exhibits an exceptional binding profile for CUL4B in human, mouse, and rat. CUL4B is a scaffold protein for the CRL4 E3 ubiquitin ligase complex, orchestrating the ubiquitination of diverse substrates including histones and cell-cycle regulators. It is a critical epigenetic regulator and its mutation is linked to syndromic X-linked intellectual disability.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58979/995_G5_2_selected.jpg
Normal Tissue
Figure 2 Epididymis
High expression in epididymis
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11880/29380_A_2_6_val_selected.jpg
Normal Tissue
Figure 3 IHC staining of human esophagus
Immunohistochemical staining of human esophagus shows nuclear positivity in squamous epithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17786/ihc_selected.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11880/29380_A_7_3.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000158290-CUL4B
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- CUL4B
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-UL113
- Applications
- Western Blot (WB), Immunohistochemistry (IHC)
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Concentration
- 0.3 mg/mL
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 40% Glycerol and 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (WB): 1/1000-1/5000
Immunohistochemistry (IHC): 1/20-1/50
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CUL4B"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0877 | Hi-Affi™ Rabbit Anti-CUL4B Recombinant Antibody (clone DS877AB) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY1689 | Rabbit Anti-CUL4B Recombinant Antibody (clone R06-3D3) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY143 | Mouse Anti-NHP CUL4B Recombinant Antibody (clone OTI7F8) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY588 | Anti-CUL4B Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1802 | Anti-Mouse CUL4B Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1801 | Anti-Human CUL4B Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1803 | Anti-Rat CUL4B Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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