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    Mouse Anti-DENR Recombinant Antibody (VS3-FY2688) (CAT#: VS3-FY2688)

    The mouse anti-DENR recombinant monoclonal antibody has been genetically engineered to specifically target DENR protein, a calculated weight of 22.1 kDa. It cross-reacts with human and mouse. This monoclonal antibody is potential for conducting research on Congenital Myopathy 23 and Capillary Malformations, Congenital. This monoclonal antibody can be used in Western Blot, Immunohistochemistry, Immunocytochemistry, Flow cytometry.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
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    Purity :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line SiHa
    Figure 1 IF staining of human cell line SiHa
    (Immunofluorescent staining of human cell line SiHa shows localization to cytosol.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/21783/if_selected.jpg
    Normal Tissue
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/21783/108745_B_7_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/21783/108745_A_7_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/21783/108745_A_7_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/21783/108745_A_9_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/21783/108745_A_4_6.jpg
    Figure 7 Placenta
    Figure 7 Placenta
    (Trophoblastic cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/21783/108745_A_1_7.jpg
    RNA Expression
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139726-DENR

    Specifications

    • Host Species
    • Mouse
    • Type
    • Mouse IgG
    • Specificity
    • Density regulated re-initiation and release factor of human and mouse origins
    • Species Reactivity
    • Human, Mouse
    • Applications
    • WB, IHC, ICC, FC
    • Conjugate
    • Unconjugated, FITC
    • MW
    • The molecular weight of the target protein is approximately 22.1 kDa.
    • Related Disease
    • Congenital Myopathy 23 and Capillary Malformations, Congenital

    Product Property

    • Clonality
    • Monoclonal Antibody
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • Western Blot: 1/100-1/2000
      Immunohistochemistry: 1/50-1/200
      Immunocytochemistry: 1/10-1/25
      Flow cytometry: 1/10-1/25

    Target

    • Alternative Names
    • Density Regulated Re-Initiation And Release Factor; Density-Regulated Protein; SMAP-3; DRP1; DRP; Smooth Muscle Cell Associated Protein-3; Smooth Muscle Cell-Associated Protein 3; Protein DRP1
    • Sequence Similarities
    • Belongs to the DENR family.
    • Cellular Localization
    • Cytosol
    • Post Translation Modifications
    • Ubiquitination at Lys59
      Modification sites at PhosphoSitePlus
      Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
    • Function
    • May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon.
      Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes.
      Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
      Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.

    Recommended Products

    Secondary Antibody

    Isotype Control

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "DENR"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    IgG Antibody Products Chicken IgY Antibody Products Antibody Magnetic Beads
    CAT Product Name Application Type
    MOB-1088MZ Recombinant Mouse Anti-Human DENR Antibody WB Mouse antibody
    VS3-CJ152 Mouse Anti-DENR Recombinant Antibody (VS3-CJ152) WB

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