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    Mouse Anti-DNMT3A Recombinant Antibody (VS3-FY2691) (CAT#: VS3-FY2691)

    The anti-DNMT3A product is a recombinant mouse monoclonal antibody that exhibits a high affinity for human DNMT3A protein, a calculated weight of 101.9 kDa. It cross-reacts with mouse and rat. This monoclonal antibody is potential for conducting research on the treatment of Tatton-Brown-Rahman Syndrome; Heyn-Sproul-Jackson Syndrome. The monoclonal antibody can be used in Western Blot assay.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/607_H4_2_selected.jpg
    Figure 2 IHC staining of human kidney
    Figure 2 IHC staining of human kidney
    (Immunohistochemical staining of human kidney shows strong nuclear positivity in cells in tubules and cells in glomeruli.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_A_8_5_selected.jpg
    Figure 3 IHC staining of human placenta
    Figure 3 IHC staining of human placenta
    (Immunohistochemical staining of human placenta shows strong nuclear positivity in trophoblastic cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9469/ihc_selected.jpg
    Figure 4 IF staining of human cell line A-431
    Figure 4 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/609_H4_1_red_green.jpg
    Figure 5 IF staining of human cell line U-251 MG
    Figure 5 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/604_H4_1_red_green.jpg
    Normal Tissue
    Figure 6 Cerebral cortex
    Figure 6 Cerebral cortex
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear
    Glial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear
    Neuronal cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear
    Neuropil
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_B_8_5.jpg
    Figure 7 Colon
    Figure 7 Colon
    (Endothelial cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Glandular cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Peripheral nerve/ganglion
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_A_8_3.jpg
    Figure 8 Liver
    Figure 8 Liver
    (Hepatocytes
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_A_8_4.jpg
    Figure 9 Kidney
    Figure 9 Kidney
    (Cells in glomeruli
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Cells in tubules
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_A_7_5.jpg
    Figure 10 Testis
    Figure 10 Testis
    (Cells in seminiferous ducts
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Leydig cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_A_6_6.jpg
    Figure 11 Lymph node
    Figure 11 Lymph node
    (Germinal center cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Non-germinal center cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_A_9_8.jpg
    RNA Expression
    Figure 12 RNA cell line category: Cell line enhanced (NTERA-2, REH, SH-SY5Y)
    Figure 12 RNA cell line category: Cell line enhanced (NTERA-2, REH, SH-SY5Y)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119772-DNMT3A

    Specifications

    • Host Species
    • Mouse
    • Type
    • Mouse IgG
    • Specificity
    • DNA Methyltransferase 3 Alpha of human, mouse and rat origins
    • Species Reactivity
    • Human, Mouse, Rat
    • Applications
    • WB
    • Conjugate
    • Unconjugated, FITC
    • MW
    • The molecular weight of the target protein is approximately 101.9 kDa.
    • Related Disease
    • Tatton-Brown-Rahman Syndrome; Heyn-Sproul-Jackson Syndrome

    Product Property

    • Clonality
    • Monoclonal Antibody
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • Western Blot: 1/500-1/2000

    Target

    • Alternative Names
    • DNA Methyltransferase 3 Alpha; DNA (Cytosine-5-)-Methyltransferase 3 Alpha; DNA MTase HsaIIIA; EC 2.1.1.37; M.HsaIIIA; DNA (Cytosine-5)-Methyltransferase 3A
    • Cellular Localization
    • Nucleus, Chromosome, Cytoplasm
    • Post Translation Modifications
    • Ubiquitination at Lys367 and Lys200
      Modification sites at PhosphoSitePlus
      Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
    • Function
    • It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18.

    Recommended Products

    Secondary Antibody

    Isotype Control

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "DNMT3A"

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    DrMAB-311 Human Anti-DNMT3A Recombinant Antibody (clone D422) ELISA, IP-MS Human IgG
    MRO-0487-CN Rabbit Anti-DNMT3A Recombinant Antibody (clone CBACN-200) WB, IF Rabbit IgG
    VS3-WK86 Mouse Anti-DNMT3A Recombinant Antibody (clone F5-G11) WB, ELISA Mouse IgG2a
    VS3-XY3335 Rabbit Anti-DNMT3A Recombinant Antibody (clone R02-3C2) WB, IHC-P, ICC, IF, FC Rabbit IgG
    VS13-YC316 Rabbit Anti-DNMT3A Recombinant Antibody (VS13-YC316) WB, ICC, IF Rabbit IgG

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