Human Anti-DOT1L Recombinant Antibody (clone 2506W1347)
CAT#: VS-0625-FY1452
This recombinant antibody is a human IgG1 antibody, generated using recombinant antibody (rAb) phage display, and its specificity and affinity for the DOT1L protein have been confirmed under non-denaturing conditions. While no specific applications are listed, this antibody serves as a precise tool for DOT1L research. The antibody targets an epitope spanning amino acids 1-420 of the DOT1L protein, offering broad recognition and making it highly valuable for studying native DOT1L or for custom assay development.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11875/1201_C5_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71217/1400_C9_1_selected.jpg
Normal Tissue
Figure 3 IHC staining of human testis
Immunohistochemical staining of human testis shows moderate positivity in subset of cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74977/166292_A_6_6_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74977/166292_B_9_5.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74977/166292_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104885-DOT1L
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Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- The antibody reacts with human DOT1L.
- Species Reactivity
- Human
- Clone
- 2506W1347
- Applications
- ELISA, Immunoprecipitation Mass Spectrometry
Product Property
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (over 6 months). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Optimal dilutions for assays should be determined by the user.
Target
- Alternative Names
- DOT1 Like Histone Lysine Methyltransferase; Histone H3-K79 Methyltransferase; Histone Methyltransferase DOT1L; Lysine N-Methyltransferase 4; DOT1-Like Protein; H3-K79-HMTase; KMT4; Histone-Lysine N-Methyltransferase, H3 Lysine-79 Specific
- Gene ID
- 84444
- UniProt ID
- Q8TEK3
- Long Name
- DOT1 Like Histone Lysine Methyltransferase
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "DOT1L"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1042CT | Recombinant Mouse anti-Human DOT1L Monoclonal antibody (EML1954) | FC, IP, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1037 | Hi-Affi™ Rabbit Anti-DOT1L Recombinant Antibody (clone DS1037AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0639J | Rabbit Anti-DOT1L Recombinant Antibody (clone 3B6) | ELISA, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY461 | Recombinant Rabbit Anti-DOT1L Antibody (clone R01-7F6) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2057 | Anti-DOT1L Immunohistochemistry Kit | IHC |
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