Rabbit Anti-DPYSL2 Recombinant Antibody (clone R01-2E6)
CAT#: VS3-XY3336
This rabbit recombinant antibody specifically recognizes DPYSL2 (Dihydropyrimidinase like 2), which plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. It reacts with human, mouse and rat DPYSL2. It has been tested using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2381/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18719/170401_B_8_5_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2381/168641_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes - Fibroblasts Staining: High Intensity: Strong Mucosal lymphoid cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Peripheral nerve/ganglion Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2381/168642_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Bowman's capsule Staining: Medium Intensity: Moderate Quantity:>75% Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2381/168642_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2381/168642_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2381/168642_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000092964-DPYSL2
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat DPYSL2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R01-2E6
- Applications
- WB, IHC-P, ICC, IF, IP, FC
- Related Disease
- Autosomal Dominant Non-Syndromic Intellectual Disability; Alzheimer Disease, Familial, 1
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2
- Gene ID
- 1808
- UniProt ID
- Q16555
- Long Name
- Dihydropyrimidinase like 2
- Cellular Localization
- Cytoplasm, cytoskeleton
- Post Translation Modifications
- Ubiquitination at Lys345 and Lys472 (NX_Q16555 [NX_Q16555-1])
Modification sites at PhosphoSitePlus (Q16555)
Glycosylation from GlyGen (Q16555) 7 sites, 1 O-linked glycan (7 sites)
- Protein Refseq
- NP_001184222.1; NP_001231533.1
- Function
- Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration.
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton.
May play a role in endocytosis.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
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- Product Name
Recommended Dilution Buffer
- CAT
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Secondary Antibody
- CAT
- Product Name
See other products for "DPYSL2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1911z | Mouse Anti-DPYSL2 Recombinant Antibody (clone 31C10) | WB, ELISA, IHC | Mouse IgG2b, κ |
| MOB-2443CT | Recombinant Mouse anti-Human DPYSL2 Monoclonal antibody (DB) | WB, IHC-P | |
| MRO-1791-CN | Rabbit Anti-DPYSL2 Polyclonal Antibody (MRO-1791-CN) | WB, IF, IHC | Rabbit IgG |
| VS3-QX330 | Mouse Anti-DPYSL2 Recombinant Antibody (clone 33CT11.40.3) | WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1043 | Hi-Affi™ Rabbit Anti-DPYSL2 Recombinant Antibody (clone DS1043AB) | WB, IHC, ICC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1044 | AbPlus™ Anti-DPYSL2 Magnetic Beads (VS-0724-YC1044) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY694 | Anti-DPYSL2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2078 | Anti-Mouse DPYSL2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2077 | Anti-Human DPYSL2 Immunohistochemistry Kit | IHC |
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