This product is a recombinant Human antibody that can recognize EBOV GP.
Figure 1 ELISA against rZEBOV GPdTM
Karczewski, J., & Yusibov, V. (2016). Plant-based technologies to enable rapid response to Ebola outbreak.
Figure 2 Efficacy in Guinea Pigs
Groups of six guinea pigs were challenged with GPA-SUDV and treated with either DPBS; 5 mg per animal of FVM04; or 1.6 mg per animal each of FVM04, c2G4, and c13C6 at 3 dpi.
Howell, K. A., Qiu, X., Brannan, J. M., Bryan, C., Davidson, E., Holtsberg, F. W., ... & Enterlein, S. G. (2016). Antibody treatment of Ebola and Sudan virus infection via a uniquely exposed epitope within the glycoprotein receptor-binding site. Cell reports, 15(7), 1514-1526.
Figure 3 ZMapp MAbs c2G4 and c4G7 competitively block entry of VLPs bearing EBOV GP.
VLPs bearing EBOV-Mayinga GP (A) or EBOV-Makona GP (B) were incubated with the indicated concentrations of the indicated MAb for 1 h at 37°C. VLPs were then bound to and allowed to enter BSC-1 cells, and the extent of entry determined as described in Materials and Methods. The percent entry values were normalized to mock-treated (0 μg/ml MAb) controls. Data are the averages of triplicate samples, with error bars representing the standard deviations (SD) of the mean. Mock-treated VLP entry values were 35% for (a) and (b). Similar results were seen for three and two repeat experiments for panels A and B, respectively. (C) VLPs were treated with either 10 or 50 μg/ml c2G4, c4G7, or a combination of the indicated amounts of c2G4 and c4G7 and then processed as described above. Values are the percent inhibition of entry relative to mock-treated (no MAb) controls. Data are the averages of three experiments performed in triplicate, with error bars representing the SD. The percent entry values in mock-treated samples in the three experiments were 46, 41, and 36%. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (A and B, relative to 0 μg/ml [no MAb] samples; C, relative to c2G4 alone).
Tran, E. E., Nelson, E. A., Bonagiri, P., Simmons, J. A., Shoemaker, C. J., Schmaljohn, C. S., ... & White, J. M. (2016). Mapping of ebolavirus neutralization by monoclonal antibodies in the ZMapp cocktail using cryo-electron tomography and studies of cellular entry. Journal of virology, 90(17), 7618-7627.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MHH-298 | Recombinant Human Anti-EBOV GP Antibody | IF, FC, Biosensors, FuncS | IgG |
HPAB-1098WJ | Mouse Anti-EBOV GP Recombinant Antibody (HPAB-1098WJ) | ELISA, WB | Mouse IgG, κ |
HPAB-0734YY | Human Anti-EBOV GP Recombinant Antibody (HPAB-0734YY) | ELISA, Neut | Human IgG1 |
HPAB-0735YY | Human Anti-EBOV GP Recombinant Antibody (HPAB-0735YY) | ELISA, Neut | Humanized IgG1 |
HPAB-0736YY | Human Anti-EBOV GP Recombinant Antibody (HPAB-0736YY) | ELISA, Neut | Humanized IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MHH-298-F(E) | Recombinant Human Anti-EBOV GP Antibody Fab Fragment | WB, IHC, FuncS | Fab |
PFBC-260 | Recombinant Human Anti-EBOV GP Antibody Fab Fragment (c2G4) | ELISA, Neut | Human Fab |
PFBC-261 | Recombinant Human Anti-EBOV GP Antibody Fab Fragment (c13C6) | ELISA, Neut | Human Fab |
PFBC-262 | Recombinant Human Anti-EBOV GP Antibody Fab Fragment (c4G7) | ELISA, Neut, WB | Human Fab |
HPAB-N0106-YC-F(E) | Macaque Anti-EBOV GP Recombinant Antibody; Fab Fragment (HPAB-N0106-YC-F(E)) | ELISA, FC, Neut | Macaque Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-927LC | Mouse Anti-EBOV GP Recombinant Antibody (MRO-927LC) | ELISA | Mouse IgG1, κ |
MRO-927LC-S(P) | Mouse Anti-EBOV GP Recombinant Antibody (MRO-927LC-S(P)); scFv Fragment | ELISA | Mouse scFv |
MRO-927LC-F(E) | Mouse Anti-EBOV GP Recombinant Antibody (MRO-927LC-F(E)); Fab Fragment | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-936LC | Human Anti-EBOV GP Recombinant Antibody (MRO-936LC) | ELISA | Human IgG1, κ |
MRO-917LC-S(P) | Anti-EBOV GP Recombinant Antibody scFv Fragment (EVB100) | ELISA | Human antibody |
MRO-918LC-S(P) | Anti-EBOV GP Recombinant Antibody scFv Fragment (EVB166) | ELISA | Human antibody |
MRO-919LC-S(P) | Anti-EBOV GP Recombinant Antibody scFv Fragment (EVB167) | ELISA | Human antibody |
MRO-920LC-S(P) | Anti-EBOV GP Recombinant Antibody scFv Fragment (EVB165) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-937LC | Anti-EBOV GP Recombinant Antibody (CAN9G1) | ELISA, WB | Mouse antibody |
MRO-938LC | Anti-EBOV GP Recombinant Antibody (CAN8G1) | ELISA, WB | Mouse antibody |
MRO-939LC | Anti-EBOV GP Recombinant Antibody (CAN7G1) | ELISA, WB | Mouse antibody |
MRO-900LC-S(P) | Anti-EBOV GP Recombinant Antibody scFv Fragment (13F6) | ELISA | Mouse antibody |
MRO-901LC-S(P) | Anti-EBOV GP Recombinant Antibody scFv Fragment (6D8) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0983LC | Recombinant Mouse Anti-EBOV GP Antibody (133/3.16) | ELISA, FuncS | IgG1 |
EPAF-0213CQ | Recombinant Mouse Anti-EBOV GP Antibody (226/8.1) | Neut | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-592-FY-S(P) | Mouse Anti-EBOV GP Recombinant Antibody; scFv Fragment (HPAB-592-FY-S(P)) | WB, ELISA, Neut | Mouse scFv |
PABJ-0009-S(P) | Human Anti-EBOV GP Recombinant Antibody (clone EBOV-520); scFv Fragment | ELISA, Neut | Human scFv |
FAMAB-0154WJ-S(P) | Human Anti-EBOV GP Recombinant Antibody (clone 2G1); scFv Fragment | ELISA, WB, Neut | Human scFv |
PABJ-0059-S(P) | Human Anti-EBOV GP Recombinant Antibody (clone 1T0227); scFv Fragment | ELISA | Human scFv |
PABJ-0144-S(P) | Human Anti-EBOV GP Recombinant Antibody (clone 3T0331); scFv Fragment | ELISA, Neut | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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