Recombinant Human Anti-EBV gH/gL Antibody (AMMO1) (CAT#: PABC-311)
This product is a recombinant Human antibody that can recognize EBV gH/gL. Anti-gH/gL antibody, AMMO1, potently neutralized infection of B cells and epithelial cells, the two major cell types targeted by EBV.
Specific Inquiry
BLI
Figure 1 We verified by biolayer interferometry (BLI) that AMMO1 specifically bound to gH/gL, and that AMMO2-AMMO5 specifically bound to gB.
Snijder, J., Ortego, M. S., Weidle, C., Stuart, A. B., Gray, M. D., McElrath, M. J., ... & McGuire, A. T. (2018). An antibody targeting the fusion machinery neutralizes dual-tropic infection and defines a site of vulnerability on Epstein-Barr virus. Immunity, 48(4), 799-811.
Neut
Figure 2 Isolated mAb Neutralizes EBV Infection in Epithelial Cells and B Cells.
Serial dilutions of the indicated antibodies were evaluated for their ability to neutralize (A) AKTA-GFP EBV infection of epithelial (SVKCR2) cells or (B) B95.8/F EBV infection of B (Raji) cells. Anti-gH/gL antibodies are shown in shades of blue, anti-gB antibodies are shown in shades of red, and the anti-gp350 antibody (72A1) is shown in gray in (B). The human or murine origins of the antibodies are indicated in the legend. Data points are mean ± SD of duplicate wells. Representative curves from 2 to 6 replicates are shown.
Snijder, J., Ortego, M. S., Weidle, C., Stuart, A. B., Gray, M. D., McElrath, M. J., ... & McGuire, A. T. (2018). An antibody targeting the fusion machinery neutralizes dual-tropic infection and defines a site of vulnerability on Epstein-Barr virus. Immunity, 48(4), 799-811.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- EBV gH/gL
- Species Reactivity
- EBV
- Clone
- AMMO1
- Applications
- ELISA, BLI, Neut
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The antibody AMMO1 has been reported in applications of Enzyme-linked Immunosorbent Assay, Biolayer interferometry, Neutralization. It's recommended that the optimal antibody concentration, dilution, incubition time etc. be carefully titrated in specific assays.
Target
- Alternative Names
- EBV gH/gL; Envelope glycoprotein H; Envelope glycoprotein L
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Recombinant Antibody
Fab Fragment Antibody
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-419 | Recombinant Mouse Anti-EBV gH/gL Antibody (CL40) | ELISA, Inhib, FC, Neut | Mouse IgG1 |
| PABC-523 | Mouse Anti-EBV gH/gL Recombinant Antibody (clone CL59) | ELISA, FC, Neut, Inhib | Mouse IgG1 |
| PABC-524 | Recombinant Mouse Anti-EBV gH/gL Antibody (E1D1) | ELISA, FC, Neut, Inhib | Mouse IgG2a, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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