Recombinant Mouse Anti-EBV gH/gL Antibody (CL40) (CAT#: PABC-419)
This product is a recombinant Mouse antibody that can recognize EBV gH/gL. CL40 can block membrane fusion with both B cells and epithelial cells. CL40 binding to gHgL/gp42 complexes is not blocked by gp42 and does not interfere with gp42 binding to HLA class II, indicating that its ability to block membrane fusion with B cells represents a defect in gB activation. CL40 binds to an epitope in gH D-II that overlaps substantially with a region observed to interact with the gp42 HP.
Specific Inquiry
Inhib
Figure 1 CL40 inhibition of membrane fusion.
Inhibition of fusion activity with purified CL40 mAb (lighter color shade) and Fab (darker color shade) using epithelial cells (A) and B cells (B).
Sathiyamoorthy, K., Jiang, J., Möhl, B. S., Chen, J., Zhou, Z. H., Longnecker, R., & Jardetzky, T. S. (2017). Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies. Proceedings of the National Academy of Sciences, 114(41), E8703-E8710.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- EBV gH/gL
- Species Reactivity
- EBV
- Clone
- CL40
- Applications
- ELISA, Inhib, FC, Neut
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Enzyme-linked Immunosorbent Assay, Inhibition, Flow Cytometry and Neutralization. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- EBV gH/gL; Envelope glycoprotein H; Envelope glycoprotein L
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Recombinant Antibody
Fab Fragment Antibody
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-311 | Recombinant Human Anti-EBV gH/gL Antibody (AMMO1) | ELISA, BLI, Neut | Human IgG |
| PABC-523 | Mouse Anti-EBV gH/gL Recombinant Antibody (clone CL59) | ELISA, FC, Neut, Inhib | Mouse IgG1 |
| PABC-524 | Recombinant Mouse Anti-EBV gH/gL Antibody (E1D1) | ELISA, FC, Neut, Inhib | Mouse IgG2a, κ |
Customer Reviews and Q&As
Customer Review
Q&As
-
User-Friendly Procedure
The product had an easy-to-use protocol that makes learning how to utilize it efficiently simple. For someone who is unfamiliar with this particular antibody, this is a huge help. -
Sturdy and Robust
During extended storage, this antibody fragment showed to be robust and stable. I saw no deterioration even after using it for several months. -
Enhanced Intricacy and Precision
The affinity-purified nature increased the trustworthiness of the results in a variety of applications by enabling strong and accurate binding.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# PABC-419, RRID: AB_3111590)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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