SmartAb™ Recombinant Anti-EGFRvIII pH-dependent Antibody (VS-0825-YC111)
CAT#: VS-0825-YC111
The anti-EGFRvIII pH-dependent antibody (VS-0825-YC111) is a recombinant monoclonal antibody that exhibits pH-dependent antigen binding to human EGFRvIII. By introducing histidine mutations that act as a pH-switch, the antibody demonstrates a preferential affinity for EGFRvIII under acidic conditions compared to physiological pH. Using a yeast surface display system with pH-dependent screening pressure, this mAb is identified which shows a significant increase in dissociation from EGFRvIII at pH 6.0. This pH-sensitive antibody retains its binding affinity for EGFRvIII on tumor cells while exhibiting negligible binding to the receptor on normal cells at physiological pH. Human EGFRvIII is a constitutively active mutant of the EGFR protein that lacks a portion of its extracellular domain. It is a common mutation in glioblastoma and other cancers and is associated with increased cell proliferation and tumor aggressiveness.
Specifications
- Immunogen
- Recombinant human EGFRvIII (ECD) protein.
- Host Species
- Human
- Type
- Human IgG1 kappa
- Specificity
- Human EGFRvIII
- Species Reactivity
- Human
- Applications
- ELISA, Inhib
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
- Alternative Names
- Class III variant of the EGFR
- Long Name
- Epidermal growth factor receptor variant III
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "EGFRvIII"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-310 | Recombinant Anti-EGFRvIII Antibody | ELISA, WB, Dot, FuncS | IgG |
| HPAB-648-FY | Human Anti-EGFRvIII Recombinant Antibody (HPAB-648-FY) | FC, ELISA | Human IgG |
| HPAB-M0065-YC | Human Anti-EGFRvIII Recombinant Antibody (HPAB-M0065-YC) | FC, Block, FuncS | Human IgG |
| HPAB-M0066-YC | Mouse Anti-EGFRvIII Recombinant Antibody (HPAB-M0066-YC) | FC | Mouse IgG |
| HPAB-M0067-YC | Human Anti-EGFRvIII Recombinant Antibody (HPAB-M0067-YC) | FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-310-F(E) | Recombinant Anti-EGFRvIII Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| HPAB-0483LY-F(E) | Human Anti-EGFRvIII Recombinant Antibody (clone CBL009LY); Fab Fragment | ELISA | Human Fab |
| HPAB-M0065-YC-F(E) | Human Anti-EGFRvIII Recombinant Antibody; Fab Fragment (HPAB-M0065-YC-F(E)) | FC, Block, FuncS | Human Fab |
| HPAB-M0066-YC-F(E) | Mouse Anti-EGFRvIII Recombinant Antibody; Fab Fragment (HPAB-M0066-YC-F(E)) | FC | Mouse Fab |
| HPAB-M0067-YC-F(E) | Human Anti-EGFRvIII Recombinant Antibody; Fab Fragment (HPAB-M0067-YC-F(E)) | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-310-S(P) | Recombinant Anti-EGFRvIII Antibody scFv Fragment | Neut, WB, FuncS | scFv |
| HPAB-0138-YJ-S(P) | Human Anti-EGFRvIII Recombinant Antibody (HPAB-0138-YJ-S(P)); scFv Fragment | ELISA, Inhib, FuncS | Human scFv |
| HPAB-M0065-YC-S(P) | Human Anti-EGFRvIII Recombinant Antibody; scFv Fragment (HPAB-M0065-YC-S(P)) | FC, Block, FuncS | Human scFv |
| HPAB-M0066-YC-S(P) | Mouse Anti-EGFRvIII Recombinant Antibody; scFv Fragment (HPAB-M0066-YC-S(P)) | FC | Mouse scFv |
| HPAB-M0067-YC-S(P) | Human Anti-EGFRvIII Recombinant Antibody; scFv Fragment (HPAB-M0067-YC-S(P)) | FC | Human scFv |
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