EGFRvIII

The class III variant of the EGFR (EGFRvIII) is the most frequently found EGFR variant in glioblastoma. EGFRvIII is characterized by a deletion of exons 2-7 of the EGFR gene, resulting in an in-frame deletion of 801 base pairs of the coding region, i.e., deletion of 6-273 amino acid residues (based on the residue numbers of mature EGFR), as well as the generation of a new glycine at the fusion junction. EGFRvIII has been shown to have a ligand-independent, weak but constitutively active kinase activity as well as enhanced tumorigenicity. In addition to gliomas, EGFRvIII has been detected in ductal and intraductal breast carcinoma, non-small cell lung carcinomas, ovarian carcinomas, prostate TME-targeting Antibody, and squamous cell carcinoma of the head and neck.