CytoStream™ Rabbit Anti-EIF4E Recombinant Antibody (VS13-YC350) (CAT#: VS13-YC350)

• Immunogen
• Recombinant eIF4E.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Mouse EIF4E

• Species Reactivity
• Human, Mouse

• Applications
• WB, IHC-P, ICC, IF, FC

• Conjugate
• NONE

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.

• Preservative
• 0.05% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/500
  Immunohistochemistry-paraffin (IHC-P): 1/200
  Immunocytochemistry (ICC): 1/50
  Flow cytometry (FC): 1/500-1/1000

• Alternative Names
• Eukaryotic Translation Initiation Factor 4E; MRNA Cap-Binding Protein; EIF-4F 25 KDa Subunit; EIF4EL1; EIF-4E; EIF4F;

• Gene ID
• 1977

• UniProt ID
• P06730

• Long Name
• Eukaryotic Translation Initiation Factor 4E

• Sequence Similarities
• Belongs to the eukaryotic initiation factor 4E family.

• Cellular Localization
• Cytoplasm; Nucleus

• Protein Refseq
• NP_001124150.1; NP_001124151.1; NP_001317946.1

• Function
• Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
  Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity).
  In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285).
  May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity).

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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