Mouse Anti-EIF4E Recombinant Antibody (VS3-CJ444)

CAT#: VS3-CJ444

This product is a mouse antibody that recognizes human, mouse, and rat EIF4E.

Gene Expression
Figure 1 IF staining of human cell line U-2 OS Figure 2 IF staining of human cell line U-251 MG Figure 3 Testis Figure 4 Colon Figure 5 Kidney Figure 6 RNA cell line category: Low cell line specificity

Specifications

  • Immunogen
  • Recombinant protein of human IF4E
  • Host Species
  • Mouse
  • Type
  • Mouse IgG
  • Specificity
  • Human, Mouse, Rat EIF4E
  • Species Reactivity
  • Human, Mouse, Rat
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Affinity purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • PBS
  • Preservative
  • 0.09% Sodium Azide
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Western Blot (1:4000), Immunocytochemistry (1:25).

Target

  • Alternative Names
  • CBP; EIF4F; AUTS19; EIF4E1; eIF-4E; EIF4EL1
  • Sequence Similarities
  • Belongs to the eukaryotic initiation factor 4E family.
  • Cellular Localization
  • Cytoplasm, Nucleus
  • Post Translation Modifications
  • Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.
  • Function
  • Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
    Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity).
    In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285).
    May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity).
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

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COA

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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