AbPlus™ Anti-EPOR Magnetic Beads (21.3.1) (CAT#: VS-0424-XY90)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magrose bead (> 50 μmol/mL gel)

• Bead Ligand
• Anti-EPOR specific antibody (21.3.1)

• Target
• EPOR

• Immunogen
• A 25 amino-acid synthetic peptide (LDKWLLPRNPPSEDLPGPGGSVDIV, aa 347-371) of the mature human erythropoietin receptor coupled to KLH via a C terminal cysteine.

• Target Species
• Human

• Antibody Clone
• 21.3.1

• Bead Capacity
• 20-30 mg/mL binding antibody

• Bead size
• 10-37 μm

• Stability
• pH 2-14

• Format
• 20% Suspension

• Buffer
• PBS, pH 7.4, with 1% BSA

• Preservative
• 0.03% Proclin 300

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.

• Alternative Names
• Erythropoietin Receptor; EPO-R

• Gene ID
• 2057

• UniProt ID
• P19235

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