Human Anti-EpoR (clone 10) scFv-Fc Chimera
CAT#: VS-0325-FY17
This is an anti-EpoR scFv-Fc antibody, which is a recombinant antibody that is specifically designed to bind to the erythropoietin receptor (EpoR). This antibody consists of a single-chain variable fragment (scFv) linked to the Fc region of an immunoglobulin, making it useful in research, diagnostics, and therapeutic applications. The binding kinetics of this scFv-Fc to the human erythropoietin receptor (huEpoR) were assessed using BIAcore, with the results showing a dissociation constant (KD) of approximately 1.1 nM.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear speckles & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77654/1825_E6_47_cr5ac349555a69b_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000187266-EPOR
Normal Tissue
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear speckles & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/77654/1825_E6_47_cr5ac349555a69b_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000187266-EPOR
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human EpoR
- Species Reactivity
- Human
- Clone
- clone 10
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer, autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Erythropoietin Receptor; EPO-R
- Gene ID
- 2057
- UniProt ID
- P19235
- Long Name
- Erythropoietin Receptor
- Sequence Similarities
- Belongs to the type I cytokine receptor family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Ubiquitinated by the ECS(SOCS2) complex following ligand-binding and phosphorylation by JAK2, leading to its degradation by the proteasome.
Regulation by the ECS(SOCS2) complex acts as a negative feedback loop of erythropoietin-mediated signaling pathway.
Ubiquitination at Lys-281 mediates receptor internalization, whereas ubiquitination at Lys-453 promotes trafficking of activated receptors to the lysosomes for degradation (By similarity).
Ubiquitinated by NOSIP; appears to be either multi-monoubiquitinated or polyubiquitinated.
Ubiquitination mediates proliferation and survival of EPO-dependent cells (By similarity).
- Protein Refseq
- NP_000112.1
- Function
- Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (PubMed:10388848, 2163695, 2163696, 8662939, 9774108).
Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity).
In some cell types, can also activate STAT1 and STAT3 (PubMed:11756159).
May also activate the LYN tyrosine kinase (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "EPOR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-007WM | Anti-Human EPOR Recombinant Antibody (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| TAB-007WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| TAB-007WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-008WM | Anti-Human EPOR Recombinant Antibody (1E3) | ELISA, WB, FC | |
| TAB-009WM | Mouse Anti-EPOR Recombinant Antibody (TAB-009WM) | WB, FC | Mouse IgG |
| TAB-008WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (1E3) | ELISA, WB, FC | |
| TAB-009WM-S(P) | Mouse Anti-EPOR Recombinant Antibody; scFv Fragment (TAB-009WM-S(P)) | WB, FC | Mouse scFv |
| TAB-008WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (1E3) | ELISA, WB, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-736CQ | Mouse Anti-EPOR Recombinant Antibody (clone CBL641) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1173 | Hi-Affi™ Rabbit Anti-EPOR Recombinant Antibody (clone DS1173AB) | IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0490-CN | Mouse Anti-EPOR Recombinant Antibody (clone 21.3.1) | ELISA, WB, ICC, IHC, IP | Mouse IgG |
| HPAB-0491-CN | Mouse Anti-EPOR Recombinant Antibody (clone 19.1.2) | ELISA, WB, ICC, IHC, IP | Mouse IgG |
| HPAB-1692-FY | Recombinant Human Anti-EPOR Antibody (Ab12) | Activ, FC, ELISA | Human IgG1 |
| HPAB-1693-FY | Human Anti-EPOR Recombinant Antibody (clone Ab12.6) | FC, ELISA | Human IgG1 |
| HPAB-1850-FY | Human Anti-EPOR Recombinant Antibody (clone Ab198) | RIA, Activ | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0490-CN-S(P) | Mouse Anti-EPOR Recombinant Antibody (clone 21.3.1); scFv Fragment | ELISA, WB, ICC, IHC, IP | Mouse scFv |
| HPAB-0491-CN-S(P) | Mouse Anti-EPOR Recombinant Antibody (clone 19.1.2); scFv Fragment | ELISA, WB, ICC, IHC, IP | Mouse scFv |
| HPAB-1306WJ-S(P) | Mouse Anti-EPOR Recombinant Antibody (clone 3G9); scFv Fragment | ELISA, WB, Agonist | Mouse scFv |
| HPAB-1307WJ-S(P) | Human Anti-EPOR Recombinant Antibody (clone 3G9HZLC); scFv Fragment | ELISA, WB, Agonist | Humanized scFv |
| HPAB-1850-FY-F(E) | Human Anti-EPOR Recombinant Antibody (clone Ab198); scFv Fragment | Activ | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0490-CN-F(E) | Mouse Anti-EPOR Recombinant Antibody (clone 21.3.1); Fab Fragment | ELISA, WB, ICC, IHC, IP | Mouse Fab |
| HPAB-0491-CN-F(E) | Mouse Anti-EPOR Recombinant Antibody (clone 19.1.2); Fab Fragment | ELISA, WB, ICC, IHC, IP | Mouse Fab |
| HPAB-0359-YJ-F(E) | Human Anti-EPOR Recombinant Antibody; Fab Fragment (HPAB-0359-YJ-F(E)) | ELISA, FC, Activ, FuncS | Human Fab |
| HPAB-0360-YJ-F(E) | Human Anti-EPOR Recombinant Antibody; Fab Fragment (HPAB-0360-YJ-F(E)) | ELISA, FC, Activ, FuncS | Human Fab |
| HPAB-1850-FY-S(P) | Human Anti-EPOR Recombinant Antibody (clone Ab198); Fab Fragment | Activ | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY90 | AbPlus™ Anti-EPOR Magnetic Beads (21.3.1) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC620 | Recombinant Anti-EPOR Vesicular Antibody, EV Displayed (VS-0425-YC620) | Agonist, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC70 | Recombinant Anti-EPOR (AA 347-371 x AA 382-402) Biparatopic Antibody, Tandem scFv (Clone 21.3.1 x Clone 19.1.2) | ELISA, ICC, IHC, IP, WB | Tandem scFv |
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