Human Anti-EpoR (clone 10) scFv-Fc Chimera (CAT#: VS-0325-FY17)
This is an anti-EpoR scFv-Fc antibody, which is a recombinant antibody that is specifically designed to bind to the erythropoietin receptor (EpoR). This antibody consists of a single-chain variable fragment (scFv) linked to the Fc region of an immunoglobulin, making it useful in research, diagnostics, and therapeutic applications. The binding kinetics of this scFv-Fc to the human erythropoietin receptor (huEpoR) were assessed using BIAcore, with the results showing a dissociation constant (KD) of approximately 1.1 nM.
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Subcellular Location
RNA Expression
Normal Tissue
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77654/1825_E6_47_cr5ac349555a69b_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77654/1825_E6_47_cr5ac349555a69b_selected.jpg
Figure 2 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000187266-EPOR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000187266-EPOR
Figure 2 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000187266-EPOR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000187266-EPOR
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/77654/1825_E6_47_cr5ac349555a69b_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/77654/1825_E6_47_cr5ac349555a69b_selected.jpg
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human EpoR
- Species Reactivity
- Human
- Clone
- clone 10
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer, autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Erythropoietin Receptor; EPO-R
- Gene ID
- 2057
- UniProt ID
- P19235
- Long Name
- Erythropoietin Receptor
- Sequence Similarities
- Belongs to the type I cytokine receptor family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Ubiquitinated by the ECS(SOCS2) complex following ligand-binding and phosphorylation by JAK2, leading to its degradation by the proteasome.
Regulation by the ECS(SOCS2) complex acts as a negative feedback loop of erythropoietin-mediated signaling pathway.
Ubiquitination at Lys-281 mediates receptor internalization, whereas ubiquitination at Lys-453 promotes trafficking of activated receptors to the lysosomes for degradation (By similarity).
Ubiquitinated by NOSIP; appears to be either multi-monoubiquitinated or polyubiquitinated.
Ubiquitination mediates proliferation and survival of EPO-dependent cells (By similarity).
- Protein Refseq
- NP_000112.1
- Function
- Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (PubMed:10388848, 2163695, 2163696, 8662939, 9774108).
Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity).
In some cell types, can also activate STAT1 and STAT3 (PubMed:11756159).
May also activate the LYN tyrosine kinase (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-007WM | Anti-Human EPOR Recombinant Antibody (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| TAB-007WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| TAB-007WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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