Recombinant Anti-EPOR Vesicular Antibody, EV Displayed (VS-0425-YC620)
CAT#: VS-0425-YC620
The Recombinant Anti-EPOR Vesicular Antibody, EV Displayed (VS-0425-YC620) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to EPOR-expressed cells or tissues. EPOR is an erythropoietin receptor affecting erythroid cell survival, with mutation-related role in erythroleukemia and familial erythrocytosis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear speckles & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77654/1825_E6_47_cr5ac349555a69b_selected.jpg
❮
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Recombinant Antibody
- Application
- Agonist, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- EPOR
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Erythropoietin receptor
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane, Nuclear speckles
- Introduction
- This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
- Gene ID
- 2057
- UniProt ID
- P19235
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "EPOR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1451z | Mouse Anti-EPOR Recombinant Antibody (clone 37G2) | WB, ELISA, IF, IP | Mouse IgG3, κ |
| HPAB-0359-YJ | Human Anti-EPOR Recombinant Antibody (HPAB-0359-YJ) | ELISA, FC, Activ, FuncS | Human IgG2 |
| HPAB-1692-FY | Recombinant Human Anti-EPOR Antibody (Ab12) | Activ, FC, ELISA | Human IgG1 |
| HPAB-1693-FY | Human Anti-EPOR Recombinant Antibody (clone Ab12.6) | FC, ELISA | Human IgG1 |
| HPAB-1694-FY | Human Anti-EPOR Recombinant Antibody (clone Ab12.56) | FC, ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-040 | Human Anti-EPOR Recombinant Antibody (clone ABT-007); Fab Fragment | WB, FuncS | Human Fab |
| HPAB-0490-CN-F(E) | Mouse Anti-EPOR Recombinant Antibody (clone 21.3.1); Fab Fragment | ELISA, WB, ICC, IHC, IP | Mouse Fab |
| HPAB-1306WJ-F(E) | Mouse Anti-EPOR Recombinant Antibody (clone 3G9); Fab Fragment | ELISA, WB, Agonist | Mouse Fab |
| HPAB-1307WJ-F(E) | Human Anti-EPOR Recombinant Antibody (clone 3G9HZLC); Fab Fragment | ELISA, WB, Agonist | Humanized Fab |
| HPAB-1850-FY-S(P) | Human Anti-EPOR Recombinant Antibody (clone Ab198); Fab Fragment | Activ | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-007WM | Anti-Human EPOR Recombinant Antibody (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| TAB-007WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| TAB-007WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-008WM | Anti-Human EPOR Recombinant Antibody (1E3) | ELISA, WB, FC | |
| TAB-009WM | Mouse Anti-EPOR Recombinant Antibody (TAB-009WM) | WB, FC | Mouse IgG |
| TAB-008WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (1E3) | ELISA, WB, FC | |
| TAB-009WM-S(P) | Mouse Anti-EPOR Recombinant Antibody; scFv Fragment (TAB-009WM-S(P)) | WB, FC | Mouse scFv |
| TAB-008WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (1E3) | ELISA, WB, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-736CQ | Mouse Anti-EPOR Recombinant Antibody (clone CBL641) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1173 | Hi-Affi™ Rabbit Anti-EPOR Recombinant Antibody (clone DS1173AB) | IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0169CQ-S(P) | Human Anti-EPOR Recombinant Antibody (clone ABT2-SCX-012); scFv Fragment | Agonist, ELISA | Human scFv |
| HPAB-0359-YJ-S(P) | Human Anti-EPOR Recombinant Antibody; scFv Fragment (HPAB-0359-YJ-S(P)) | ELISA, FC, Activ, FuncS | Human scFv |
| HPAB-0360-YJ-S(P) | Human Anti-EPOR Recombinant Antibody; scFv Fragment (HPAB-0360-YJ-S(P)) | ELISA, FC, Activ, FuncS | Human scFv |
| HPAB-1692-FY-F(E) | Recombinant Human Anti-EPOR Antibody scFv Fragment (Ab12) | FC, ELISA | Human scFv |
| HPAB-1693-FY-F(E) | Human Anti-EPOR Recombinant Antibody (clone Ab12.6); scFv Fragment | FC, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY90 | AbPlus™ Anti-EPOR Magnetic Beads (21.3.1) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY17 | Human Anti-EpoR (clone 10) scFv-Fc Chimera | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC70 | Recombinant Anti-EPOR (AA 347-371 x AA 382-402) Biparatopic Antibody, Tandem scFv (Clone 21.3.1 x Clone 19.1.2) | ELISA, ICC, IHC, IP, WB | Tandem scFv |
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