Recombinant Anti-EPOR (AA 347-371 x AA 382-402) Biparatopic Antibody, Tandem scFv (Clone 21.3.1 x Clone 19.1.2)
CAT#: VS-0525-YC70
The Recombinant Anti-EPOR (AA 347-371 x AA 382-402) Biparatopic Antibody, Tandem scFv (Clone 21.3.1 x Clone 19.1.2) is a biparatopic antibody (bpAb) engineered to target two separate epitopes on EPOR. This bpAb incorporates a tandem scFv: the 21.3.1 scFv (specific for EPOR amino acids 347-371) is N-terminally conjoined to the 19.1.2 scFv (recognizing EPOR amino acids 382-402).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear speckles & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77654/1825_E6_47_cr5ac349555a69b_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000187266-EPOR
Normal Tissue
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear speckles & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/77654/1825_E6_47_cr5ac349555a69b_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000187266-EPOR
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Specifications
- Host Animal 1
- Mouse
- Host Animal 2
- Mouse
- Specificity
- Human EPOR
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- 21.3.1
- Clone 2
- 19.1.2
- Epitope 1
- aa 347-371 of EPOR
- Epitope 2
- aa 382-402 of EPOR
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, ICC, IHC, IP, WB
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Erythropoietin Receptor
Target
- Introduction
- This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
- Alternative Names
- Erythropoietin Receptor; EPO-R
- Gene ID
- 2057
- UniProt ID
- P19235
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Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-007WM | Anti-Human EPOR Recombinant Antibody (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| TAB-007WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| TAB-007WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-008WM | Anti-Human EPOR Recombinant Antibody (1E3) | ELISA, WB, FC | |
| TAB-009WM | Mouse Anti-EPOR Recombinant Antibody (TAB-009WM) | WB, FC | Mouse IgG |
| TAB-008WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (1E3) | ELISA, WB, FC | |
| TAB-008WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (1E3) | ELISA, WB, FC | |
| TAB-009WM-F(E) | Mouse Anti-EPOR Recombinant Antibody; Fab Fragment (TAB-009WM-F(E)) | WB, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-736CQ | Mouse Anti-EPOR Recombinant Antibody (clone CBL641) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1173 | Hi-Affi™ Rabbit Anti-EPOR Recombinant Antibody (clone DS1173AB) | IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0169CQ-S(P) | Human Anti-EPOR Recombinant Antibody (clone ABT2-SCX-012); scFv Fragment | Agonist, ELISA | Human scFv |
| HPAB-0359-YJ-S(P) | Human Anti-EPOR Recombinant Antibody; scFv Fragment (HPAB-0359-YJ-S(P)) | ELISA, FC, Activ, FuncS | Human scFv |
| HPAB-1306WJ-S(P) | Mouse Anti-EPOR Recombinant Antibody (clone 3G9); scFv Fragment | ELISA, WB, Agonist | Mouse scFv |
| HPAB-1307WJ-S(P) | Human Anti-EPOR Recombinant Antibody (clone 3G9HZLC); scFv Fragment | ELISA, WB, Agonist | Humanized scFv |
| HPAB-1850-FY-F(E) | Human Anti-EPOR Recombinant Antibody (clone Ab198); scFv Fragment | Activ | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0359-YJ-F(E) | Human Anti-EPOR Recombinant Antibody; Fab Fragment (HPAB-0359-YJ-F(E)) | ELISA, FC, Activ, FuncS | Human Fab |
| HPAB-0360-YJ-F(E) | Human Anti-EPOR Recombinant Antibody; Fab Fragment (HPAB-0360-YJ-F(E)) | ELISA, FC, Activ, FuncS | Human Fab |
| HPAB-1692-FY-S(P) | Recombinant Human Anti-EPOR Antibody Fab Fragment (Ab12) | FC, ELISA | Human Fab |
| HPAB-1693-FY-S(P) | Human Anti-EPOR Recombinant Antibody (clone Ab12.6); Fab Fragment | FC, ELISA | Human Fab |
| HPAB-1694-FY-S(P) | Human Anti-EPOR Recombinant Antibody (clone Ab12.56); Fab Fragment | FC, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY90 | AbPlus™ Anti-EPOR Magnetic Beads (21.3.1) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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