AbPlus™ Anti-ESR1 Magnetic Beads (33) (CAT#: VS-0424-XY93)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magrose bead (> 50 μmol/mL gel)

• Bead Ligand
• Anti-ESR1 specific antibody (33)

• Target
• ESR1

• Immunogen
• Synthetic peptide corresponding to the residues 247-261 (EVGMMKGGIRKDRRG) of the ER alpha DNA binding domain

• Target Species
• Human, Mouse, Rat, Fish, Primate, Sheep, Bovine, Avian

• Antibody Clone
• 33

• Bead Capacity
• 20-30 mg/mL binding antibody

• Bead size
• 10-37 μm

• Stability
• pH 2-14

• Format
• 20% Suspension

• Buffer
• PBS, pH 7.4, with 1% BSA

• Preservative
• 0.03% Proclin 300

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• ESR1 estrogen receptor 1 This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. ER; ESR; Era; ESRA; ESTRR; NR3A1

• Alternative Names
• ESR1; estrogen receptor 1; ER; ESR; Era; ESRA; ESTRR; NR3A1

• Gene ID
• 2099

• UniProt ID
• P03372

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