AbPlus™ Anti-FADD Magnetic Beads (VS-0724-YC514) (CAT#: VS-0724-YC514)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magnetic bead

• Bead Ligand
• Anti-FADD specific antibody

• Target
• FADD

• Immunogen
• Recombinant human FADD fragment derived from E. coli.

• Target Species
• Human

• Bead Capacity
• 40 mg/mL

• Bead size
• 25 μm

• Format
• Suspension

• Concentration
• 2 mg/mL

• Buffer
• PBS, pH 7.4

• Preservative
• 0.1% Sodium azide

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

• Alternative Names
• Fas Associated Via Death Domain; Fas-Associating Death Domain-Containing Protein; Growth-Inhibiting Gene 3 Protein; Fas-Associating Protein With Death Domain; Fas (TNFRSF6)-Associated Via Death Domain; Mediator Of Receptor-Induced Toxicity;

• Gene ID
• 8772

• UniProt ID
• Q13158

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