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FADD
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cytotrophoblasts, Ductal cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (A-431)
Interaction
Can self-associate (PubMed:19118384, PubMed:20935634). Interacts with CFLAR, PEA15 and MBD4 (PubMed:10442631, PubMed:12702765). When phosphorylated, part of a complex containing HIPK3 and FAS (PubMed:11034606). May interact with MAVS/IPS1 (PubMed:16127453). Interacts with MOCV v-CFLAR protein and PIDD1 (PubMed:10825539). Interacts (via death domain) with FAS (via death domain) (PubMed:21109225, PubMed:16762833, PubMed:20935634). Interacts with CASP8 (PubMed:16762833). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity). Interacts with RIPK1, TRADD and CASP8 (By similarity). Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis) (By similarity). Interacts with stimulated TNFRSF10B (PubMed:18846110). Interacts with stimulated TNFRSF10B (By similarity). (Microbial infection) Interacts with human papillomavirus 16/HPV16 protein E6. (Microbial infection) Interacts with molluscum contagiosum virus proteins MC159L/v-CFLAR and MC160L.
More Types Infomation
Related Diseases
Colorectal Cancer
Amyotrophic Lateral Sclerosis
Maturity Onset Diabetes of the Young
Related Signaling Pathways
TNF Signaling Pathway
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, IP, IF, ELISA
- Rabbit Anti-FADD Polyclonal Antibody (MRO-1852-CN) (MRO-1852-CN)
-
- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: WB, FC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, IP
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IHC-P, IP, WB
- Rabbit Anti-FADD Recombinant Antibody (clone AFY0013) (MOR-0042-FY)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, IP
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
-
- Species Reactivity: Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC-P
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For Research Use Only. Not For Clinical Use.