Anti-FCGR2B Antibody Prodrug, Protease Activated (VS-1025-YC164)
CAT#: VS-1025-YC164
The Anti-FCGR2B Antibody Prodrug, Protease Activated (VS-1025-YC164) is an antibody prodrug comprised of a recombinant human antibody targeting human FCGR2B, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to FCGR2B protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to FCGR2B effectively. FCGR2B (Fc Receptor, low affinity, inhibitory) is an inhibitory receptor on immune cells that is a key modulator of the efficacy of therapeutic antibodies. Its high expression on B-cells and monocytes can dampen the anti-tumor effects of antibodies like rituximab.
Gene Expression
Normal Tissue
Figure 1 Placenta
Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Hofbauer cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining: Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7796/18532_A_3_7.jpg
Normal Tissue
Figure 2 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7796/18532_A_8_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (Daudi, HMC-1, NB-4, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000072694-FCGR2B
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human FCGR2B
- Target
- FCGR2B
- Species Reactivity
- Human
- Isotype
- Chimeric (rat/human) IgG1, kappa
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- Fc Fragment Of IgG, Low Affinity IIb, Receptor For (CD32); Fc Gamma Receptor IIb; IgG Fc Receptor II-B; Fc-Gamma RII-B; Fc-Gamma-RIIb; FcRII-B; CDw32; IGFR2; FCG2; CD32; FCGR2; CD32B
- Gene ID
- 2213
- UniProt ID
- P31994
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1025-YC164. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "FCGR2B"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1086z | Mouse Anti-FCGR2B Recombinant Antibody (MOB-1086z) | ELISA, WB, IP, IF, IHC, FC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1086z-F(E) | Recombinant Anti-Human FCGR2B Antibody Fab Fragment | FC, Neut, Funcs | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1086z-S(P) | Recombinant Anti-Human FCGR2B Antibody scFv Fragment | FC, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-267CL | Human Anti-FCGR2B Recombinant Antibody (TAB-267CL) | FC, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-034WM | Human Anti-FCGR2B Recombinant Antibody (TAB-034WM) | ELISA, FC, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-035WM | Mouse Anti-FCGR2B Recombinant Antibody (TAB-035WM) | ELISA, FC, Inhib | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-036WM | Mouse Anti-FCGR2B Recombinant Antibody (TAB-036WM) | ELISA, FC, Inhib | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-037WM | Human Anti-FCGR2B Recombinant Antibody (TAB-037WM) | ELISA, FuncS | Chimeric (human/mouse) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-038WM | Human Anti-FCGR2B Recombinant Antibody (TAB-038WM) | ELISA, FuncS | Humanized Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-034WM-S(P) | Human Anti-FCGR2B Recombinant Antibody; scFv Fragment (TAB-034WM-S(P)) | ELISA, FC, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-035WM-S(P) | Mouse Anti-FCGR2B Recombinant Antibody; scFv Fragment (TAB-035WM-S(P)) | ELISA, FC, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-036WM-S(P) | Mouse Anti-FCGR2B Recombinant Antibody; scFv Fragment (TAB-036WM-S(P)) | ELISA, FC, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-037WM-S(P) | Anti-FCGR2B Recombinant Antibody; scFv Fragment (TAB-037WM-S(P)) | ELISA, FC, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-038WM-S(P) | Human Anti-FCGR2B Recombinant Antibody; scFv Fragment (TAB-038WM-S(P)) | ELISA, FC, WB | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-034WM-F(E) | Human Anti-FCGR2B Recombinant Antibody; Fab Fragment (TAB-034WM-F(E)) | ELISA, FC, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-035WM-F(E) | Mouse Anti-FCGR2B Recombinant Antibody; Fab Fragment (TAB-035WM-F(E)) | ELISA, FC, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-037WM-F(E) | Human Anti-FCGR2B Recombinant Antibody; Fab Fragment (TAB-037WM-F(E)) | ELISA, FC, WB | Chimeric Antibody (human/mouse) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-038WM-F(E) | Human Anti-FCGR2B Recombinant Antibody; Fab Fragment (TAB-038WM-F(E)) | ELISA, FC, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1273 | Hi-Affi™ Rabbit Anti-FCGR2B Recombinant Antibody (clone DS1273AB) | WB, IHC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0586-CN | Human Anti-FCGR2B Recombinant Antibody (HPAB-0586-CN) | ELISA, WB, FC, Co-IP | Chimeric (rat/human) IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0587-CN | Human Anti-FCGR2B Recombinant Antibody (HPAB-0587-CN) | ELISA, WB, FC, Co-IP | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0587-CN-S(P) | Human Anti-FCGR2B Recombinant Antibody; scFv Fragment (HPAB-0587-CN-S(P)) | ELISA, WB, FC, Co-IP | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0587-CN-F(E) | Human Anti-FCGR2B Recombinant Antibody; Fab Fragment (HPAB-0587-CN-F(E)) | ELISA, WB, FC, Co-IP | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0585-CN | Human Anti-FCGR2B Recombinant Antibody (HPAB-0585-CN) | ELISA, WB, FC, Co-IP | Chimeric (rat/human) IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0588-CN | Human Anti-FCGR2B Recombinant Antibody (HPAB-0588-CN) | ELISA, WB, FC, Co-IP | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0585-CN-S(P) | Rat Anti-FCGR2B Recombinant Antibody; scFv Fragment (HPAB-0585-CN-S(P)) | ELISA, WB, FC, Co-IP | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0588-CN-S(P) | Human Anti-FCGR2B Recombinant Antibody; scFv Fragment (HPAB-0588-CN-S(P)) | ELISA, WB, FC, Co-IP | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0585-CN-F(E) | Human Anti-FCGR2B Recombinant Antibody; Fab Fragment (HPAB-0585-CN-F(E)) | ELISA, WB, FC, Co-IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0588-CN-F(E) | Human Anti-FCGR2B Recombinant Antibody; Fab Fragment (HPAB-0588-CN-F(E)) | ELISA, WB, FC, Co-IP | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0083-LS-S(P) | Rat Anti-FCGR2B Recombinant Antibody; scFv Fragment (HPAB-0083-LS-S(P)) | ELISA, FC, WB | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0083-LS-F(E) | Rat Anti-FCGR2B Recombinant Antibody; Fab Fragment (HPAB-0083-LS-F(E)) | ELISA, FC, WB | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY826 | Anti-FCGR2B Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC387 | CytoStream™ Rat Anti-Fcgr2b Recombinant Antibody (VS13-YC387) | FC | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC343 | Recombinant Anti-FCGR2B Vesicular Antibody, EV Displayed (VS-0425-YC343) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2482 | Anti-Rat FCGR2B Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2481 | Anti-Human FCGR2B Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, WB
Application: ELISA, IP, FC, FuncS, Neut, IF, IHC
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: Neut, ELISA, FuncS
Application: FuncS, Inhib, IP, ELISA
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
