What is the biological role of FCGR2B?

FCGR2B (Fc Gamma Receptor IIb) is a low-affinity receptor for the Fc region of immunoglobulin gamma complexes. It is involved in phagocytosis of immune complexes and regulates antibody production by B-cells.

What is the composition of this antibody product?

This product is a recombinant Chimeric (rat/human) IgG1, kappa antibody. It is expressed in Human cells and purified by affinity chromatography for use in various assays like ELISA and Co-IP.

Human Anti-FCGR2B Recombinant Antibody (HPAB-0585-CN)

CAT#: HPAB-0585-CN

This product is a recombinant human antibody that recognizes FCGR2B. The antibody was purified by affinity chromatography. It can be used for ELISA, WB, FC, Co-IP and other applications.

Gene Expression

Normal Tissue Figure 1 Placenta

Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Hofbauer cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining: Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: High
Intensity: Strong

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7796/18532_A_3_7.jpg

Normal Tissue Figure 2 Lymph node

Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7796/18532_A_8_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (Daudi, HMC-1, NB-4, RPMI-8226)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000072694-FCGR2B

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Specifications

Host Species
Human

Derivation
Chimeric (rat/human)

Type
Chimeric (rat/human) IgG1, κ

Specificity
Human FCGR2B

Species Reactivity
Human

Applications
ELISA, WB, FC, Co-IP

Related Disease
Autoimmune disease

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Fc Fragment Of IgG Receptor IIb; Fc Fragment Of IgG, Low Affinity IIb, Receptor (CD32); Fc Fragment Of IgG, Low Affinity IIb, Receptor For (CD32); Fc Gamma Receptor IIb; IgG Fc Receptor II-B; Fc-Gamma RII-B; Fc-Gamma-RIIb; FcRII-B; CDw32; IGFR2; FCG2; CD32; Fc Fragment Of IgG, Low Affinity II, Receptor For (CD32); Fc Gamma RIIb; CD32 Antigen; FCGR2; CD32B

Gene ID
2213

UniProt ID
P31994

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Breast cancer biomarkers at key points during disease progression

Versatile For Many Applications

This recombinant human antibody is incredibly versatile. We have used it in ELISA, Western Blot, Flow Cytometry, and Co-Immunoprecipitation (Co-IP). It consistently detects FCGR2B, the low-affinity receptor for IgG, helping us study immune complex phagocytosis.

High Purity Chimeric Antibody

As a chimeric rat/human IgG1, this antibody offers unique properties for our research. It is purified to>95% by SDS-PAGE. We rely on it to investigate the regulation of antibody production by B-cells and its association with autoimmune models.

Q&As

What is the biological role of FCGR2B?

A: FCGR2B (Fc Gamma Receptor IIb) is a low-affinity receptor for the Fc region of immunoglobulin gamma complexes. It is involved in phagocytosis of immune complexes and regulates antibody production by B-cells.
What is the composition of this antibody product?

A: This product is a recombinant Chimeric (rat/human) IgG1, kappa antibody. It is expressed in Human cells and purified by affinity chromatography for use in various assays like ELISA and Co-IP.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-0585-CN.pdf

MSDS

MSDS - HPAB-0585-CN.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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