Mouse Anti-GAST Recombinant Antibody (VS3-CJ262) (CAT#: VS3-CJ262)

• Immunogen
• KLH-conjugated synthetic peptide encompassing a sequence within human Gastrin

• Host Species
• Mouse

• Type
• Mouse IgG3

• Specificity
• Human GAST

• Species Reactivity
• Human

• Applications
• IHC

• Conjugate
• Unconjugated

• Purification
• Immunogen affinity chromatography

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• 50% Glycerol, 0.2% BSA, PBS.

• Preservative
• 0.01% sodium azide

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• This antibody has been tested for use in Immunohistochemistry (1:100-1:300).

• Alternative Names
• GAS; Gastrin

• Gene ID
• 2520

• UniProt ID
• P01350

• Sequence Similarities
• Belongs to the gastrin/cholecystokinin family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
  Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.

• Protein Refseq
• NP_000796.1

• Function
• Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

Secondary Antibody

• 2RD-A1470-YJ
• Goat Anti-Mouse IgG3 Secondary antibody

• 2RD-A1569-YJ
• Rabbit Anti-Mouse IgG3 Secondary antibody (Clone RM218)

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

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