Human Anti-GNB2 Recombinant Antibody (clone B27) (CAT#: FAMAB-0342JF)
Recombinant monoclonal antibody specially binds to β2GP-1. This human anti-β2GP-1 antibody (B27) can be potentially used in the treatment of thrombosis, recurrent fetal loss, and thrombocytopenia in patients with antiphospholipid syndrome (APS).
Specific Inquiry
ELISA
Figure 1 Anti-human PD1 antibodies are associated with the induction of a clinical response in a patient with acute myeloid leukemia.
Reduction of the immunosuppression for prophylaxis of graftversus-host disease preceded the complete hematologic response, which has been maintained with 17 months of follow-up.
Neuberg, R. S., DeAngelo, D., & Dranoff, G. Protein disulfide isomerases are antibody targets during immune-mediated.
WB
Figure 2 RENCA vaccine targets show enhanced expression in tumor cells compared to normal tissues.
The 18S ribosomal RNA served as a loading control.
Neuberg, R. S., DeAngelo, D., & Dranoff, G. Protein disulfide isomerases are antibody targets during immune-mediated.
FC
Figure 3 Vaccination with irradiated, GM-CSF secreting RENCA cells stimulates potent anti-tumor humoral immunity.
Sera were collected from syngeneic Balb/c mice that were either naïve or immunized ten times at weekly intervals with irradiated GM-CSF secreting or parental RENCA cells.
Neuberg, R. S., DeAngelo, D., & Dranoff, G. Protein disulfide isomerases are antibody targets during immune-mediated.
IHC
Figure 4 The significant downregulation of GNB2 expression in renal cell carcinoma (RCC) compared with normal (NL) kidney tissue.
Exploration stage of the study reproducing TCGA and Human Protein Atlas datasets.
Chen, C., Chi, H., Min, L., & Junhua, Z. (2017). Downregulation of guanine nucleotide-binding protein beta 1 (GNB1) is associated with worsened prognosis of clearcell renal cell carcinoma and is related to VEGF signaling pathway. J BUON, 22(6), 1441-1446.
Specifications
- Host Species
- Human
- Derivation
- Human phage display Fab library
- Type
- Human IgG
- Specificity
- Human GNB2
- Species Reactivity
- Human
- Clone
- B27
- Applications
- WB, ELISA, IHC, FC
- Related Disease
- Antiphospholipid syndrome
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The GNB2 antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Flow Cytometry.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1465 | Hi-Affi™ Rabbit Anti-GNB2 Recombinant Antibody (clone DS1465AB) | IHC-P, WB, ICC, FC, IP | Rabbit IgG |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1965 | PE-A2/Human GNB2 (ALWDIETGQQTV) MHC Tetramer | FCM |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0342JF-F(E) | Human Anti-GNB2 Recombinant Antibody (clone B27); Fab Fragment | ELISA, FuncS | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0342JF-S(P) | Human Anti-GNB2 Recombinant Antibody (clone B27); scFv Fragment | ELISA, FuncS | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK372 | Rabbit Anti-GNB2 Recombinant Antibody (clone JE47-16) | WB, IHC, FC | Rabbit IgG |
| VS3-FY600 | Recombinant Rabbit Anti-GNB2 Antibody (clone R04-1A2) | WB, IHC-P, IP | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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