Human Anti-gp100 Recombinant Soluble TCR (clone (gp100)-4)
CAT#: scTCR-0495YC-S(P)
Recombinant Human single-chain TCR (scTCR) gp100 recognizes gp100 (280–288) peptide variant YLE-8A (YLEPGPVAA) in the context of HLA-A*02:01. The scTCR is responsible for the specificity of T cells.
Specifications
- Host Species
- Human
- Target
- gp100
- Epitope
- YLEPGPVAA
- MHC
- HLA-A*02:01
- Clone
- gp100
- Type
- Single-Chain TCR
- Related Disease
- Melanoma
Target
- Alternative Names
- gp100 (280–288) peptide variant YLE-8A; YLEPGPVAA
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Study Of Peptide Ligands
This product enabled us to study how altered peptide ligands influence T-cell responses. The clone specifically targeted the YLEPGPVAA sequence, which was vital for our experiments on breaking tolerance toward self-antigens.
Helpful For Melanoma Research
We are investigating peptide-based vaccines for melanoma, and this human scTCR against gp100 was very helpful. It allowed us to analyze the recognition of the YLE-8A variant in the context of HLA-A*02:01 with high precision.
Q&As
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What is the rationale for using altered peptide ligands?
A: There is an emphasis on using altered peptide ligands because most anti-cancer TCRs have relatively weak affinity. Immunizing with these ligands aims to induce strong anti-tumor immunity capable of breaking tolerance toward self-antigens like gp100.
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Which specific variant of gp100 does this clone target?
A: This recombinant human scTCR targets the gp100 (280-288) peptide variant YLE-8A. The specific amino acid sequence is YLEPGPVAA, and it is recognized in the context of the HLA-A*02:01 MHC molecule.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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See other products for "Clone gp100"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0757 | PE-Mamu-A*08/SIV gp100 (KPCVKLTP) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0758 | APC-Mamu-A*08/SIV gp100 (KPCVKLTP) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
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| MHC-CN0759 | FITC-Mamu-A*08/SIV gp100 (KPCVKLTP) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
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| MHC-CN0760 | Mamu-A*08/SIV gp100 (KPCVKLTP) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF854 | DRB1*04:01/Human gp100 (IYRRRLMKQDFSVPQLPHS) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF1006 | APC-DRB1*04:01/Human gp100 (IYRRRLMKQDFSVPQLPHS) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF1158 | PE-DRB1*04:01/Human gp100 (IYRRRLMKQDFSVPQLPHS) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF1310 | FITC-DRB1*04:01/Human gp100 (IYRRRLMKQDFSVPQLPHS) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF1462 | BV421-DRB1*04:01/Human gp100 (IYRRRLMKQDFSVPQLPHS) MHC Tetramer | FCM |
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