AibGenesis™ Rabbit Anti-GPX4 Recombinant Antibody (VS-0426-FY875)
CAT#: VS-0426-FY875
VS-0426-FY875 is a Rabbit IgG antibody targeting GPX4, developed through our AI-powered antibody discovery platform. Protein A purified (Clone AibG-Rb-GP81), it is validated for WB, ICC, IF, ELISA, and IP in Human, Mouse, and Rat. It is a gold-standard reagent for studying ferroptosis, oxidative stress, and antioxidant defense.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58546/if_selected.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47224/141864_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47224/141864_A_6_6.jpg
RNA Expression
Figure 4 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167468-GPX4
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| Sub Cat | Species Reactivity | Clone | Applications | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS-0426-FY81 | Human, Mouse, Rat | AibG-Rb-GP81 | WB, ICC, IF, ELISA, IP | ||||||
| VS-0426-FY82 | Human, Mouse, Rat | AibG-Rb-GP82 | WB, IHC, ICC, IF |
More Infomation
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- GPX4
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Male Infertility
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Target
- Alternative Names
- Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; PHGPx; Glutathione peroxidase 4; GPx-4; GSHPx-4
- Gene ID
- 2879
- UniProt ID
- P36969
- Long Name
- Glutathione Peroxidase 4
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Ubiquitination at Lys162 and Lys167 (NX_P36969 [NX_P36969-1])
Modification sites at PhosphoSitePlus (P36969)
- Protein Refseq
- NP_001034936.1
- Function
- Required for normal sperm development and male fertility (By similarity).
Essential for maturation and survival of photoreceptor cells (By similarity).
Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity).
Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (PubMed:11115402).
Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "GPX4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0762MZ | Recombinant Mouse Anti-Human GPX4 Antibody (clone 8B5) | ELISA, IP, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1499 | Rabbit Anti-GPX4 Recombinant Antibody (clone DS1499AB) | WB, IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0688-CN | Rabbit Anti-GPX4 Recombinant Antibody (clone JU11-31) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1906-CN | Rabbit Anti-GPX4 Polyclonal Antibody (MRO-1906-CN) | WB, IF, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0367JF | Mouse Anti-GPx4 Recombinant Antibody (clone 63-1) | WB, IHC, IF | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0367JF-F(E) | Mouse Anti-GPx4 Recombinant Antibody (clone 63-1); Fab Fragment | IB, IP, IHC, ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0367JF-S(P) | Mouse Anti-GPx4 Recombinant Antibody (clone 63-1); scFv Fragment | IB, IP, IHC, ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0692J | Rabbit Anti-GPX4 Recombinant Antibody (clone 9D4) | ELISA, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2900 | Anti-GPX4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2901 | Anti-Mouse GPX4 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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