Rabbit Anti-GRIA1 Recombinant Antibody (clone R01-3U6)
CAT#: VS3-XY3373
The product is a recombinant rabbit antibody targeting the GRIA1 (Glutamate ionotropic receptor AMPA type subunit 1). It recognizes and binds to human GRIA1. It also has cross-reactivity against mouse and rat GRIA1. It has been determined using Western Blot, Immunohistochemistry-Paraffin and Immunoprecipitation. The recommended dilutions of Western Blot, Immunohistochemistry-Paraffin and Immunoprecipitation is 1/500-1/1000, 1/50-1/100 and 1/20, respectively.
Gene Expression
Normal Tissue
Figure 1 Hippocampal formation
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35202/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35202/135520_B_7_5.jpg
Normal Tissue
Figure 3 Hippocampus
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35202/135520_B_7_6.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35202/135520_A_8_5.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35202/135520_A_8_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (AF22, ASC diff, BJ, BJ hTERT+, LHCN-M2, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000155511-GRIA1
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat GRIA1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R01-3U6
- Applications
- WB, IHC-P, IP
- Related Disease
- Intellectual Developmental Disorder, Autosomal Recessive 76
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IP: 1/20
Target
- Alternative Names
- GLUH1; GLUR1; GLURA; GluA1; HBGR1; MRD67; MRT76
- Gene ID
- 2890
- UniProt ID
- P42261
- Long Name
- Glutamate ionotropic receptor AMPA type subunit 1
- Sequence Similarities
- Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
- Cellular Localization
- Cell membrane, Cell projection, Endoplasmic reticulum, Endosome, Membrane, Postsynaptic cell membrane, Synapse
- Post Translation Modifications
- Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2 (By similarity).
Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation (By similarity).
- Protein Refseq
- NP_000818.2; NP_001107655.1; NP_001244948.1
- Function
- Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "GRIA1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2122z | Mouse Anti-GRIA1 Recombinant Antibody (clone 37D7) | WB, ICC, IF, IHC | Mouse IgG1 |
| MRO-0674-CN | Rabbit Anti-GRIA1 Recombinant Antibody (clone CBACN-245) | WB, IHC, IP | Rabbit IgG |
| MRO-2328-CN | Rabbit Anti-GRIA1 Recombinant Antibody (clone CBACN-619) | WB, FC | Rabbit IgG |
| VS-0522-LC189 | Rat Anti-Gria1 Recombinant Antibody (VS-0522-LC189) | WB, IHC | Rat IgG2b |
| VS-0522-LC190 | Rabbit Anti-Gria1 Recombinant Antibody (VS-0522-LC190) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1504 | Rabbit Anti-GRIA1 Recombinant Antibody (clone DS1504AB) | IHC-P, IP, WB | Rabbit IgG |
| MOR-0035-FY | Rabbit Anti-GRIA1 Recombinant Antibody (clone AFY0006) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY115 | AbPlus™ Anti-GRIA1 Magnetic Beads (CBACN-245) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2913 | Anti-GRIA1 Immunohistochemistry Kit | IHC |
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