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GRIA1
Loading...Anti-GRIA1 Products
- Rabbit Anti-GRIA1 Recombinant Antibody (clone CBACN-245) (MRO-0674-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IP
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- Rabbit Anti-GRIA1 Recombinant Antibody (clone CBACN-619) (MRO-2328-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, FC
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- Rabbit Anti-Gria1 Recombinant Antibody (VS-0522-LC190) (VS-0522-LC190)
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- Species Reactivity: Rat, Mouse
- Type: Rabbit IgG
- Application: WB, IHC
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- AbPlus™ Anti-GRIA1 Magnetic Beads (CBACN-245) (VS-0424-XY115)
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- Target: GRIA1
- Target Species: Human, Mouse, Rat
- Application: IP, Protein Purification
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- Rat Anti-Gria1 Recombinant Antibody (VS-0522-LC189) (VS-0522-LC189)
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- Species Reactivity: Rat, Mouse
- Type: Rat IgG2b
- Application: WB, IHC
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- Rabbit Anti-GRIA1 Recombinant Antibody (VS13-YC466) (VS13-YC466)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
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- Anti-GRIA1 Immunohistochemistry Kit (VS-0525-XY2913)
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- Species Reactivity: Human
- Target: GRIA1
- Application: IHC
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- Rabbit Anti-GRIA1 Recombinant Antibody (clone AFY0006) (MOR-0035-FY)
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- Species Reactivity: Rat, Human
- Type: Rabbit IgG
- Application: IHC-P, WB
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For Research Use Only. Not For Clinical Use.
Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein class
FDA approved drug targets, Plasma proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Group enriched (Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, ASC diff, BJ, BJ hTERT+, LHCN-M2, U-266/70)
Interaction
Homotetramer or heterotetramer of pore-forming glutamate receptor subunits (By similarity). Tetramers may be formed by the dimerization of dimers (PubMed:23739980). Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with HIP1 and RASGRF2. Interacts with SYNDIG1 and GRIA2 (By similarity). Interacts with DLG1 (via C-terminus). Interacts with LRFN1. Interacts with PRKG2 (By similarity). Interacts with CNIH2 and CACNG2 (PubMed:20805473). Interacts with CACNG5. Interacts (via C-terminus) with PDLIM4 (via LIM domain); this interaction as well as the interaction of PDLIM4 with alpha-actinin is required for their colocalization in early endosomes. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. Interacts (via PDZ-binding motif) with SHANK3 (via PDZ domain) (By similarity). Interacts with CACNG3; associates GRIA1 with the adapter protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons (By similarity).
Molecular function
Ion channel, Ligand-gated ion channel, Receptor
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