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    Rabbit Anti-HMBS Recombinant Antibody (VS3-CJ495) (CAT#: VS3-CJ495)

    This product is a rabbit antibody that recognizes human, mouse, and rat HMBS.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line A-431
    Figure 1 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to lipid droplets.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50659/769_A11_5_selected.jpg
    Normal Tissue
    Figure 2 IHC staining of human pancreas
    Figure 2 IHC staining of human pancreas
    (Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6114/ihc_selected.jpg
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50659/128403_B_7_5.jpg
    Figure 4 Colon
    Figure 4 Colon
    (Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50659/128403_A_9_3.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50659/128403_A_8_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Leydig cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50659/128403_A_5_6.jpg
    Figure 7 Bone marrow
    Figure 7 Bone marrow
    (Hematopoietic cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50659/128403_B_5_4.jpg
    RNA Expression
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000256269-HMBS

    Specifications

    • Immunogen
    • Recombinant protein
    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Human, Mouse, Rat HMBS
    • Species Reactivity
    • Human, Mouse, Rat
    • Applications
    • WB
    • Conjugate
    • Unconjugated

    Product Property

    • Purification
    • Protein A affinity purified
    • Purity
    • >95% as determined by SDS-PAGE
    • Format
    • Liquid
    • Buffer
    • 40% Glycerol, 1% BSA, TBS, pH7.4.
    • Preservative
    • 0.05% Sodium Azide
    • Storage
    • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • This antibody has been tested for use in Western Blot.

    Target

    • Alternative Names
    • UPS; PBGD; PORC; PBG-D
    • Sequence Similarities
    • Belongs to the HMBS family.
    • Cellular Localization
    • Cytoplasm
    • Function
    • As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen (PubMed:18936296, PubMed:19138865, PubMed:23815679).
      Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact (PubMed:18936296).

    Recommended Products

    Isotype Control

    Secondary Antibody

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "HMBS"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    IgG Antibody Products Rabbit Monoclonal Antibody Products Antibody Magnetic Beads
    CAT Product Name Application Type
    MOB-0835CT Recombinant Mouse anti-Human HMBS Monoclonal antibody (EML393) WB
    MRO-0754-CN Rabbit Anti-HMBS Recombinant Antibody (clone CBACN-278) WB Rabbit IgG
    VS4-WK221 Rabbit Anti-HMBS Recombinant Antibody (clone 8G12) ELISA, WB Rabbit IgG

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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