AibGenesis™ Rabbit Anti-HMGCS2 Recombinant Antibody (AibG-Rb-HM495)
CAT#: VS-0426-FY495
Engineered through our AI-powered antibody discovery platform, this Rabbit IgG targets HMGCS2. Validated for WB, IHC, and IF-P across Human, Mouse, and Rat, it is an essential tool for researching the rate-limiting enzyme in ketogenesis and its metabolic role in the liver and intestinal epithelium.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm & mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27423/2048_B2_3_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27442/1395_F6_3_selected.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27442/59065_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27442/59065_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Collecting ducts Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27442/59065_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27442/59065_A_5_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (OE19, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134240-HMGCS2
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human HMGCS2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-HM495
- Applications
- Western Blot, Immunohistochemistry, Immunofluorescence-Paraffin
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Mitochondrial HMG-CoA Synthase Deficiency
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS, pH 7.4, 150 mM NaCl, 50% Glycerol
- Preservative
- 0.02% New type preservative N
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:1000-1:5000), Immunohistochemistry (1:50-1:200), Immunofluorescence-Paraffin (1:50-1:200)
Target
- Alternative Names
- HMG CoA synthase; HMGCS2
- Gene ID
- 3158
- UniProt ID
- P54868
- Long Name
- 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2
- Sequence Similarities
- Belongs to the HMG-CoA synthase family.
- Cellular Localization
- Mitochondrion
- Post Translation Modifications
- Succinylated.
Desuccinylated by SIRT5.
Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity.
Modification sites at PhosphoSitePlus (P54868)
Modification sites at neXtProt (NX_P54868)
Glycosylation from GlyGen (P54868) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001159579.1; NP_005509.1
- Function
- Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "HMGCS2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0257MZ | Chicken Anti-HMGCS2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1637 | Rabbit Anti-HMGCS2 Recombinant Antibody (clone DS1637AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS4-WK223 | Rabbit Anti-HMGCS2 Recombinant Antibody (clone 19C11) | ELISA, WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC537 | Rabbit Anti-HMGCS2 Recombinant Antibody (VS13-YC537) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3213 | Anti-HMGCS2 Immunohistochemistry Kit | IHC |
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