Rabbit Anti-HMMR Recombinant Antibody (clone R08-7D4) (CAT#: VS3-XY3382)
This product is a recombinant rabbit antibody binding to HMMR (Hyaluronan mediated motility receptor), which involves in cellular transformation and metastasis formation. This antibody specifically recognizes the epitope of human HMMR. It also has cross-reactivity against mouse and rat HMMR. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin and Immunoprecipitation.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to centrosome & microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43926/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to centrosome & microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43926/if_selected.jpg
Figure 2 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61524/1723_D6_28_cr57eab4e82b568_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61524/1723_D6_28_cr57eab4e82b568_selected.jpg
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2433/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2433/if_selected.jpg
Figure 4 Testis
(Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2433/6892_A_6_6.jpg
(Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2433/6892_A_6_6.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000072571-HMMR
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000072571-HMMR
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat HMMR
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-7D4
- Applications
- WB, IHC-P, IP
- Related Disease
- Breast Cancer, Fibrosarcoma
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IP: 1/20
Target
- Alternative Names
- CD168; IHABP; RHAMM
- Gene ID
- 3161
- UniProt ID
- O75330
- Long Name
- Hyaluronan mediated motility receptor
- Cellular Localization
- Cytoplasm, cytoskeleton, Cell surface
- Post Translation Modifications
- Glycosylation at Asn133, Asn477, Asn567, and Asn588 (NX_O75330 [NX_O75330-1])
Modification sites at PhosphoSitePlus (O75330)
Glycosylation from GlyGen (O75330) 5 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001136028.1; NP_001136029.1
- Function
- Receptor for hyaluronic acid (HA) (By similarity).
Involved in cell motility (By similarity).
When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 oCcurs.
May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
MHC Tetramer Products for Cancer
Rabbit Monoclonal Antibody Products
ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3749z | Mouse Anti-HMMR Recombinant Antibody (clone 22A5) | WB, ELISA, FC, ICC, IHC | Mouse IgG1 |
| MOB-0458CT | Recombinant Mouse anti-Human HMMR Monoclonal antibody (3E7) | FC, ICC/IF, IHC-Fr, IHC-P | |
| HPAB-0061-YJ | Mouse Anti-HMMR Recombinant Antibody (clone 16E10) | IA | Mouse IgG1, κ |
| VS3-XY810 | Mouse Anti-HMMR Recombinant Antibody (clone 2F6B8) | ELISA, WB, FC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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