Anti-ICOSLG Antibody Prodrug, Protease Activated (VS-1025-YC203)
CAT#: VS-1025-YC203
The Anti-ICOSLG Antibody Prodrug, Protease Activated (VS-1025-YC203) is an antibody prodrug comprised of a recombinant human antibody targeting human ICOSLG, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to ICOSLG protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to ICOSLG effectively. ICOSLG is a co-stimulatory ligand expressed on antigen-presenting cells and sometimes tumor cells. Its binding to its receptor (ICOS) on T-cells contributes to T-cell activation and is important for the anti-tumor immune response, making it a target for novel immunotherapies.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to plasma membrane & cytoplasmic bodies.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29179/1168_B11_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows moderate cytoplasmic positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79997/170635_B_6_4_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_5_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (Daudi)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160223-ICOSLG
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human ICOSLG
- Target
- ICOSLG
- Species Reactivity
- Human
- Isotype
- IgG2
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include Inclusion Body Myositis and Immunodeficiency With Hyper-Igm, Type 2. Among its related pathways are Allograft rejection and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is LOC102723996.
- Alternative Names
- Inducible T Cell Costimulator Ligand
- Gene ID
- 23308
- UniProt ID
- O75144
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1025-YC203. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "ICOSLG"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1783z | Mouse Anti-ICOSLG Recombinant Antibody (clone 18A7) | FC, IHC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0427ZL | Mouse Anti-ICOSLG Recombinant Antibody (clone 3D6) | WB, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2312MZ | Recombinant Mouse Anti-Human ICOSLG Antibody (clone GM13C1) | ELISA, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-946CQ | Mouse Anti-ICOSLG Recombinant Antibody (clone CBL071) | Neut, WB | Mouse IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-947CQ | Mouse Anti-ICOSLG Recombinant Antibody (clone MM0103-19G23) | WB, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-948CQ | Mouse Anti-ICOSLG Recombinant Antibody (clone CBL694) | WB, Neut | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-949CQ | Mouse Anti-ICOSLG Recombinant Antibody (clone CBL695) | FC, CyTOF, Neut | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-952CQ | Mouse Anti-ICOSLG Recombinant Antibody (clone MIH12) | FC, FuncS, IHC-Fr, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1728 | Rabbit Anti-ICOSLG Recombinant Antibody (clone DS1728AB) | WB, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-446CQ | Human Anti-ICOSLG Recombinant Antibody (TAB-446CQ) | ELISA, IHC, FC, IP, IF, Inhib | Human IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-446CQ | Afuco™ Anti-ICOSLG Recombinant Antibody (AFC-TAB-446CQ), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0634-WJ | Human Anti-ICOSLG Recombinant Antibody (HPAB-0634-WJ) | ELISA | Human IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0635-WJ | Human Anti-ICOSLG Recombinant Antibody (HPAB-0635-WJ) | ELISA | Human IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0634-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0634-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0635-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0635-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0636-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0636-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0637-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0637-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0638-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0638-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0634-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0634-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0635-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0635-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0636-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0636-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0637-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0637-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0638-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0638-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC565 | CytoStream™ Rabbit Anti-ICOSLG Recombinant Antibody (VS13-YC565) | FC, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY134 | Human Anti-ICOSLG scFv-Fc Chimera (VS-0425-FY134) | ELISA, FC, WB | Human IgG2, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC146 | Recombinant Anti-ICOSLG Vesicular Antibody, EV Displayed (VS-0425-YC146) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3375 | Anti-ICOSLG Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3376 | Anti-Mouse ICOSLG Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC161 | SmartAb™ Recombinant Anti-ICOSLG pH-dependent Antibody (VS-0825-YC161) | ELISA, IHC, FC, IP, IF, Inhib | Human IgG2 kappa |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: Neut, ELISA, IF, IP, FuncS, FC, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: Block, Cyt, FuncS, Inhib
Application: ELISA, Neut, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
