Human Anti-ICOSLG scFv-Fc Chimera (VS-0425-FY134)
CAT#: VS-0425-FY134
The anti-ICOSLG scFv-FC is a therapeutic agent targeting ICOS ligand (ICOSLG), which plays an important role in T cell activation and regulation of immune responses. By blocking the interaction between ICOS and its ligand, this scFv-FC can potentially modulate T cell activity, offering a novel strategy for treating autoimmune disorders and enhancing anti-tumor immunity in cancer therapy.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to plasma membrane & cytoplasmic bodies.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29179/1168_B11_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows moderate cytoplasmic positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79997/170635_B_6_4_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_5_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (Daudi)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160223-ICOSLG
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Specifications
- Immunogen
- Human B7-H2 / ICOSL / CD275.
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human ICOSLG
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry, Western Blot
- Related Disease
- Inclusion Body Myositis and Immunodeficiency With Hyper-Igm, Type 2
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Inducible T Cell Costimulator Ligand
- Gene ID
- 23308
- UniProt ID
- O75144
- Long Name
- Inducible T Cell Costimulator Ligand
- Sequence Similarities
- Belongs to the immunoglobulin superfamily. BTN/MOG family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn137, Asn173, Asn186, Asn70, Asn102, and Asn225
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect ICOSL_HUMAN (740)
Glycosylation from GlyGen 9 sites, 10 N-linked glycans (4 sites), 1 O-linked glycan (3 sites)
- Protein Refseq
- XP_011527816.1; XP_011527818.1; XP_047296685.1; XP_047296686.1; XP_047296687.1
- Function
- Ligand for the T-cell-specific cell surface receptor ICOS.
Acts as a costimulatory signal for T-cell proliferation and cytokine secretion.
Also induces B-cell proliferation and differentiation into plasma cells.
Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1783z | Mouse Anti-ICOSLG Recombinant Antibody (clone 18A7) | FC, IHC | Mouse IgG2b |
| MOB-0427ZL | Mouse Anti-ICOSLG Recombinant Antibody (clone 3D6) | WB, IHC | Mouse IgG2a |
| HPAB-0634-WJ | Human Anti-ICOSLG Recombinant Antibody (HPAB-0634-WJ) | ELISA | Human IgG2 |
| HPAB-0635-WJ | Human Anti-ICOSLG Recombinant Antibody (HPAB-0635-WJ) | ELISA | Human IgG2 |
| VS3-FY719 | Recombinant Rabbit Anti-ICOSLG Antibody (clone R03-9A5) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-946CQ | Mouse Anti-ICOSLG Recombinant Antibody (clone CBL071) | Neut, WB | Mouse IgG2 |
| NEUT-947CQ | Mouse Anti-ICOSLG Recombinant Antibody (clone MM0103-19G23) | WB, Neut | Mouse IgG1 |
| NEUT-948CQ | Mouse Anti-ICOSLG Recombinant Antibody (clone CBL694) | WB, Neut | Mouse IgG2b |
| NEUT-949CQ | Mouse Anti-ICOSLG Recombinant Antibody (clone CBL695) | FC, CyTOF, Neut | Mouse IgG2b |
| NEUT-952CQ | Mouse Anti-ICOSLG Recombinant Antibody (clone MIH12) | FC, FuncS, IHC-Fr, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1728 | Rabbit Anti-ICOSLG Recombinant Antibody (clone DS1728AB) | WB, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-446CQ | Human Anti-ICOSLG Recombinant Antibody (TAB-446CQ) | ELISA, IHC, FC, IP, IF, Inhib | Human IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-446CQ | Afuco™ Anti-ICOSLG Recombinant Antibody (AFC-TAB-446CQ), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0634-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0634-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0635-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0635-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0636-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0636-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0637-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0637-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0638-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0638-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0634-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0634-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0635-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0635-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0636-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0636-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0637-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0637-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0638-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0638-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC565 | CytoStream™ Rabbit Anti-ICOSLG Recombinant Antibody (VS13-YC565) | FC, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC146 | Recombinant Anti-ICOSLG Vesicular Antibody, EV Displayed (VS-0425-YC146) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3375 | Anti-ICOSLG Immunohistochemistry Kit | IHC | |
| VS-0525-XY3376 | Anti-Mouse ICOSLG Immunohistochemistry Kit | IHC |
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