Does this antibody neutralize the interaction of ICOSLG?

Yes, this mouse monoclonal antibody (clone MM0103-19G23) binds specifically to B7-H2 (ICOSLG) and can neutralize its bioactivity. It acts as an inhibitor in functional assays, preventing the ligand from interacting with its receptor.

What is the immunogen used for this antibody?

The immunogen used is Human ICOSLG. The antibody specifically recognizes this ligand, which is important for T-cell proliferation and cytokine secretion. It is validated for Western Blot and Neutralization applications.

Mouse Anti-ICOSLG Recombinant Antibody (clone MM0103-19G23)

CAT#: NEUT-947CQ

This antibody is a mouse monoclonal antibody that binds specifically to B7-H2, and it can neutralize the bioactivity of B7-H2.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line SiHa

Immunofluorescent staining of human cell line SiHa shows localization to plasma membrane & cytoplasmic bodies.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29179/1168_B11_4_selected.jpg

Normal Tissue Figure 2 IHC staining of human bone marrow

Immunohistochemical staining of human bone marrow shows moderate cytoplasmic positivity in hematopoietic cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79997/170635_B_6_4_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_B_9_5.jpg

Normal Tissue Figure 4 Colon

Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_9_3.jpg

Normal Tissue Figure 5 Liver

Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_8_4.jpg

Normal Tissue Figure 6 Kidney

Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_7_5.jpg

Normal Tissue Figure 7 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_5_6.jpg

Normal Tissue Figure 8 Lymph node

Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_9_8.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (Daudi)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160223-ICOSLG

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Specifications

Immunogen
Human ICOSLG

Host Species
Mouse

Type
Mouse IgG1

Specificity
Human ICOSLG

Species Reactivity
Human

Clone
MM0103-19G23

Applications
WB, Neut

Conjugate
Unconjugated

Product Property

Purification
Protein G purified

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
ICOSLG; inducible T-cell costimulator ligand; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L

Gene ID
23308

UniProt ID
O75144

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Breast cancer biomarkers at key points during disease progression

Binds And Neutralizes B7-H2

We used clone MM0103-19G23 to neutralize B7-H2 interactions in our cell culture model. The antibody effectively blocked the ligand, as confirmed by downstream signaling readouts. It is a highly specific mouse monoclonal antibody.

Clean Western Blot Data

This recombinant antibody provided clean bands in our Western Blot analysis of ICOSLG expression. The Protein G purification ensures a high-quality product that free of interfering contaminants for our protein analysis.

Q&As

Does this antibody neutralize the interaction of ICOSLG?

A: Yes, this mouse monoclonal antibody (clone MM0103-19G23) binds specifically to B7-H2 (ICOSLG) and can neutralize its bioactivity. It acts as an inhibitor in functional assays, preventing the ligand from interacting with its receptor.
What is the immunogen used for this antibody?

A: The immunogen used is Human ICOSLG. The antibody specifically recognizes this ligand, which is important for T-cell proliferation and cytokine secretion. It is validated for Western Blot and Neutralization applications.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - NEUT-947CQ.pdf

MSDS

MSDS - NEUT-947CQ.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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