Recombinant Anti-ICOSLG Vesicular Antibody, EV Displayed (VS-0425-YC146)
CAT#: VS-0425-YC146
The Recombinant Anti-ICOSLG Vesicular Antibody, EV Displayed (VS-0425-YC146) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ICOSLG-expressed cells or tissues. The ICOSLG is a protein involved in receptor binding, linked to diseases like Inclusion Body Myositis. The protein is associated with pathways like Allograft rejection and Innate Immune System.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to plasma membrane & cytoplasmic bodies.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29179/1168_B11_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows moderate cytoplasmic positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79997/170635_B_6_4_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_5_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26037/59019_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (Daudi)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160223-ICOSLG
❮
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ICOSLG
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Inducible T cell costimulator ligand
- Biological Process
- Adaptive immunity, B-cell activation, Immunity
- Cellular Localization
- Vesicles, Plasma membrane
- Introduction
- ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include Inclusion Body Myositis and Immunodeficiency With Hyper-Igm, Type 2. Among its related pathways are Allograft rejection and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is LOC102723996.
- Alternative Names
- B7-H2, B7h, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, KIAA0653
- Gene ID
- 23308
- UniProt ID
- O75144
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-946CQ | Mouse Anti-ICOSLG Recombinant Antibody (clone CBL071) | Neut, WB | Mouse IgG2 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1728 | Rabbit Anti-ICOSLG Recombinant Antibody (clone DS1728AB) | WB, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-446CQ | Human Anti-ICOSLG Recombinant Antibody (TAB-446CQ) | ELISA, IHC, FC, IP, IF, Inhib | Human IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-446CQ | Afuco™ Anti-ICOSLG Recombinant Antibody (AFC-TAB-446CQ), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0634-WJ | Human Anti-ICOSLG Recombinant Antibody (HPAB-0634-WJ) | ELISA | Human IgG2 |
| HPAB-0635-WJ | Human Anti-ICOSLG Recombinant Antibody (HPAB-0635-WJ) | ELISA | Human IgG2 |
| HPAB-0636-WJ | Human Anti-ICOSLG Recombinant Antibody (HPAB-0636-WJ) | ELISA | Human IgG2 |
| HPAB-0637-WJ | Human Anti-ICOSLG Recombinant Antibody (HPAB-0637-WJ) | ELISA | Human IgG2 |
| HPAB-0638-WJ | Human Anti-ICOSLG Recombinant Antibody (HPAB-0638-WJ) | ELISA | Human IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0634-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0634-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0635-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0635-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0636-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0636-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0637-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0637-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0638-WJ-F(E) | Human Anti-ICOSLG Recombinant Antibody; Fab Fragment (HPAB-0638-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0634-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0634-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0635-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0635-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0636-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0636-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0637-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0637-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0638-WJ-S(P) | Human Anti-ICOSLG Recombinant Antibody; scFv Fragment (HPAB-0638-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC565 | CytoStream™ Rabbit Anti-ICOSLG Recombinant Antibody (VS13-YC565) | FC, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY134 | Human Anti-ICOSLG scFv-Fc Chimera (VS-0425-FY134) | ELISA, FC, WB | Human IgG2, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3375 | Anti-ICOSLG Immunohistochemistry Kit | IHC | |
| VS-0525-XY3376 | Anti-Mouse ICOSLG Immunohistochemistry Kit | IHC |
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