Anti-ID1 (clone W24V184) Recombinant Antibody Coupled Liposome (VS-1024-FY185)
CAT#: VS-1024-FY185
ID1 is a transcription factor that plays a critical role in the initiation and progression of melanoma, a particularly aggressive form of skin cancer. By conjugating anti-ID1 antibodies to liposomes, researchers have developed a novel strategy that enables the precise targeting of malignant cells, thereby enhancing the delivery of therapeutic agents directly to the tumor site. This targeted approach has the potential to not only inhibit tumor growth but also to reduce the risk of metastasis, offering a more effective treatment option for patients battling this challenging disease.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/51456/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58518/if_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25915/64826_A_8_3.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25915/64826_A_4_6.jpg
Normal Tissue
Figure 5 Placenta
Trophoblastic cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25915/64826_A_2_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (EFO-21, HaCaT, Hep G2, PC-3)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000125968-ID1
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V184
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was specifically engineered to target and bind to the protein inhibitor of DNA binding 1 (ID1). ID1 is known to play a crucial role in various cellular processes, including cell differentiation, proliferation, and the regulation of stem cell properties.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- ID1
- Introduction
- Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
- Alternative Names
- DNA-binding protein inhibitor ID-1; Class B basic helix-loop-helix protein 24; bHLHb24; Inhibitor of DNA binding 1; Inhibitor of differentiation 1; ID1; BHLHB24 ID
- Full Name
- Inhibitor Of DNA Binding 1, HLH Protein
- Gene ID
- 3397
- UniProt ID
- P41134
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (P41134)
Modification sites at neXtProt (NX_P41134)
- Protein Refseq
- NP_002156.2
- Function
- Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity.
Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.
Inhibits skeletal muscle and cardiac myocyte differentiation.
Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity).
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Datasheet
MSDS
COA
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See other products for "ID1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3006z | Mouse Anti-ID1 Recombinant Antibody (clone 29D9) | WB, ELISA, IF, IHC, IP | Mouse IgG2a, κ |
| HPAB-0307-YC | Rabbit Anti-ID1 Recombinant Antibody (clone #BCH-2/#5-3) | ELISA, WB, IHC | Rabbit IgG |
| HPAB-0309-YC | Rabbit Anti-ID1 Recombinant Antibody (clone #BCH-1/#195-14) | ELISA, WB, IHC | Rabbit IgG |
| HPAB-0418-CN | Rabbit Anti-Id1 Recombinant Antibody (clone #BCH-1/#37-2) | WB, ELISA, IHC | Rabbit IgG |
| MRO-0808-CN | Rabbit Anti-ID1 Recombinant Antibody (clone JM92-13) | WB, IF, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1729 | Rabbit Anti-Id1 Recombinant Antibody (clone DS1729AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0307-YC-S(P) | Rabbit Anti-ID1 Recombinant Antibody (clone #BCH-2/#5-3); scFv Fragment | ELISA, WB, IHC | Rabbit scFv |
| HPAB-0309-YC-S(P) | Rabbit Anti-ID1 Recombinant Antibody (clone #BCH-1/#195-14); scFv Fragment | ELISA, WB, IHC | Rabbit scFv |
| HPAB-0418-CN-S(P) | Rabbit Anti-Id1 Recombinant Antibody (clone #BCH-1/#37-2); scFv Fragment | WB, ELISA, IHC | Rabbit scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0307-YC-F(E) | Rabbit Anti-ID1 Recombinant Antibody (clone #BCH-2/#5-3); Fab Fragment | ELISA, WB, IHC | Rabbit Fab |
| HPAB-0309-YC-F(E) | Rabbit Anti-ID1 Recombinant Antibody (clone #BCH-1/#195-14); Fab Fragment | ELISA, WB, IHC | Rabbit Fab |
| HPAB-0418-CN-F(E) | Rabbit Anti-Id1 Recombinant Antibody (clone #BCH-1/#37-2); Fab Fragment | WB, ELISA, IHC | Rabbit Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1086 | Anti-ID1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3378 | Anti-Mouse ID1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3377 | Anti-Human ID1 Immunohistochemistry Kit | IHC |
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