Rabbit Anti-IDE Recombinant Antibody (clone R04-4E8) (CAT#: VS3-FY2017)
This particular antibody is a rabbit recombinant monoclonal variant with a strong binding affinity to human IDE. It is recommended for utilization in a range of assays, such as WB and ICC/IF. The antibody targeting insulin degrading enzyme was identified through immunocytochemistry analysis of Insulin degrading enzyme/IDE (green) in hela cells.
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ICC
Figure 1 Anti-IDE Antibody (VS3-FY2017) in ICC.
Immunocytochemistry staining of Insulin degrading enzyme/IDE (green) in hela using the anti-Insulin degrading enzyme/IDE antibody. Nuclear DNA was labeled with DAPI (shown in blue).
Specifications
- Immunogen
- Synthetic peptide of human insulin degrading enzyme/IDE
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IDE
- Species Reactivity
- Human
- Clone
- R04-4E8
- Applications
- Western Blot, Immunofluorescence
- MW
- The calculated weight of the target protein is approximately 118 kDa, while the observed molecular weight stands at 118 kDa.
- Related Disease
- Alzheimer's diseases
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunofluorescence: 1/50-1/200
Target
- Alternative Names
- Insulin Degrading Enzyme
- Gene ID
- 3416
- UniProt ID
- P14735
- Sequence Similarities
- Belongs to the peptidase M16 family.
- Cellular Localization
- Cell membrane, Cytoplasm, Membrane, Secreted
- Post Translation Modifications
- The N-terminus is blocked. (P14735-IDE_HUMAN)
Ubiquitination at Lys192, Lys308, Lys884, Lys929, Lys938, and Lys1018 (NX_P14735 [NX_P14735-1])
Modification sites at PhosphoSitePlus (P14735)
Glycosylation from GlyGen (P14735) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_016871676.1; XP_016871677.1; XP_016871679.2; XP_047281125.1; XP_047281127.1
- Function
- Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia. Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
Human Antibody Products
Rabbit Monoclonal Antibody Products
Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-535 | Recombinant Anti-human IDE Antibody | WB, Dot, FuncS | IgG |
| PABL-594 | Mouse Anti-IDE Recombinant Antibody (clone YC112) | WB, FuncS | Mouse IgG |
| FAMAB-1164CQ | Human Anti-IDE Recombinant Antibody (clone Fab-IDE) | ELISA | Human IgG1 |
| PABS-0199 | Human Anti-IDE Recombinant Antibody (clone H11-E) | ELISA, FuncS | Human IgG |
| MOB-0051F | Mouse Anti-IDE Recombinant Antibody (clone 3H4) | WB, IHC-P, IF | Mouse IgG |
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