Mouse Anti-IDE Recombinant Antibody (VS3-CJ656) (CAT#: VS3-CJ656)
This product is a mouse antibody that recognizes human, mouse, and rat IDE.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows membranous and cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_1_1_selected.jpg
(Immunohistochemical staining of human stomach shows membranous and cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_1_1_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membrano)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_B_8_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membrano)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_B_8_5.jpg
Figure 3 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_7_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_7_3.jpg
Figure 4 Liver
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_9_4.jpg
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_9_4.jpg
Figure 5 Kidney
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_8_5.jpg
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_8_5.jpg
Figure 6 Testis
(Sertoli cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_6_6.jpg
(Sertoli cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_6_6.jpg
Figure 7 Skin
(Melanocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membrano)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_B_7_1.jpg
(Melanocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membrano)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_B_7_1.jpg
Figure 8 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_8_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_8_8.jpg
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119912-IDE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119912-IDE
Specifications
- Immunogen
- Synthetic peptide
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human, Mouse, Rat IDE
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Fractional precipitation
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunohistochemistry.
Target
- Alternative Names
- INSULYSIN
- Gene ID
- 3416
- UniProt ID
- P14735
- Sequence Similarities
- Belongs to the peptidase M16 family.
- Cellular Localization
- Cell membrane, Cytoplasm, Membrane, Secreted
- Post Translation Modifications
- The N-terminus is blocked.
- Protein Refseq
- NP_001159418.1; NP_004960.2
- Function
- Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling.
Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (PubMed:23922390, PubMed:26394692, PubMed:29596046).
Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity).
Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (PubMed:9830016, PubMed:26394692) (Probable). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (PubMed:21098034).
Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (PubMed:21098034).
Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I.
(Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV).
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "IDE"
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-535-F(E) | Recombinant Anti-human IDE Antibody Fab Fragment | Neut, WB, FuncS | Fab |
| MHH-535-F(E) | Recombinant Human Anti-human IDE Antibody Fab Fragment | ELISA, RIA, FuncS | Fab |
| PFBL-589 | Mouse Anti-IDE Recombinant Antibody (clone YC113); Fab Fragment | WB, FuncS | Mouse Fab |
| PFBS-0055 | Mouse Anti-IDE Recombinant Antibody (Clone Fab(IDE)); Fab Fragment | ELISA, FuncS | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-535-S(P) | Recombinant Anti-human IDE Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
| MHH-535-S(P) | Recombinant Human Anti-human IDE Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| PSBL-589 | Mouse Anti-IDE Recombinant Antibody (clone YC113); scFv Fragment | WB, FuncS | Mouse scFv |
| PSBS-0055 | Mouse Anti-IDE Recombinant Antibody (Clone Fab(IDE)); scFv Fragment | ELISA, FuncS | Mouse scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-110 | Recombinant Human Anti-IDE Antibody | WB, Neut, FuncS | IgG |
| PABX-110-S (P) | Recombinant Human Anti-IDE Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| PABX-110-F (E) | Recombinant Human Anti-IDE Antibody Fab Fragment | WB, Neut, FuncS | Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1732 | Rabbit Anti-IDE Recombinant Antibody (clone DS1732AB) | WB, ICC | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1164CQ | Human Anti-IDE Recombinant Antibody (clone Fab-IDE) | ELISA | Human IgG1 |
| PABS-0055 | Mouse Anti-IDE Recombinant Antibody (Clone Fab(IDE)) | ELISA, FuncS | Mouse IgG |
| PABS-0199 | Human Anti-IDE Recombinant Antibody (clone H11-E) | ELISA, FuncS | Human IgG |
| PABS-0200 | Human Anti-IDE Recombinant Antibody (clone H11) | ELISA, FuncS | Human IgG |
| PABS-0213 | Human Anti-IDE Recombinant Antibody (clone 02J13) | ELISA | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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