Mouse Anti-IDE Recombinant Antibody (VS3-CJ656)
CAT#: VS3-CJ656
This product is a mouse antibody that recognizes human, mouse, and rat IDE.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human stomach
Immunohistochemical staining of human stomach shows membranous and cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_1_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membrano
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Sertoli cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_6_6.jpg
Normal Tissue
Figure 7 Skin
Melanocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membrano
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_B_7_1.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119912-IDE
❮
❯
Specifications
- Immunogen
- Synthetic peptide
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human, Mouse, Rat IDE
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Fractional precipitation
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunohistochemistry.
Target
- Alternative Names
- INSULYSIN
- Gene ID
- 3416
- UniProt ID
- P14735
- Sequence Similarities
- Belongs to the peptidase M16 family.
- Cellular Localization
- Cell membrane, Cytoplasm, Membrane, Secreted
- Post Translation Modifications
- The N-terminus is blocked.
- Protein Refseq
- NP_001159418.1; NP_004960.2
- Function
- Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling.
Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (PubMed:23922390, PubMed:26394692, PubMed:29596046).
Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity).
Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (PubMed:9830016, PubMed:26394692) (Probable). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (PubMed:21098034).
Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (PubMed:21098034).
Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I.
(Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV).
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS3-CJ656. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "IDE"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-535 | Recombinant Anti-human IDE Antibody | WB, Dot, FuncS | IgG |
| MHH-535 | Recombinant Human Anti-human IDE Antibody | WB, FC, FuncS | IgG |
| MRO-0844-CN | Rabbit Anti-IDE Recombinant Antibody (clone JJ0949) | WB, IHC | Rabbit IgG |
| MOB-0051F | Mouse Anti-IDE Recombinant Antibody (clone 3H4) | WB, IHC-P, IF | Mouse IgG |
| VS4-WK236 | Mouse Anti-IDE Recombinant Antibody (VS4-WK236) | ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-535-F(E) | Recombinant Anti-human IDE Antibody Fab Fragment | Neut, WB, FuncS | Fab |
| MHH-535-F(E) | Recombinant Human Anti-human IDE Antibody Fab Fragment | ELISA, RIA, FuncS | Fab |
| PFBL-589 | Mouse Anti-IDE Recombinant Antibody (clone YC113); Fab Fragment | WB, FuncS | Mouse Fab |
| PFBS-0055 | Mouse Anti-IDE Recombinant Antibody (Clone Fab(IDE)); Fab Fragment | ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-535-S(P) | Recombinant Anti-human IDE Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
| MHH-535-S(P) | Recombinant Human Anti-human IDE Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| PSBL-589 | Mouse Anti-IDE Recombinant Antibody (clone YC113); scFv Fragment | WB, FuncS | Mouse scFv |
| PSBS-0055 | Mouse Anti-IDE Recombinant Antibody (Clone Fab(IDE)); scFv Fragment | ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-110 | Recombinant Human Anti-IDE Antibody | WB, Neut, FuncS | IgG |
| PABX-110-S (P) | Recombinant Human Anti-IDE Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| PABX-110-F (E) | Recombinant Human Anti-IDE Antibody Fab Fragment | WB, Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1732 | Rabbit Anti-IDE Recombinant Antibody (clone DS1732AB) | WB, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY267 | Mouse Anti-NHP IDE Recombinant Antibody (clone OTI4E5) | WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3380 | Anti-IDE Immunohistochemistry Kit | IHC | |
| VS-0525-XY3381 | Anti-Mouse IDE Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
-CB2006C17L-4.jpg)
Application: WB, ELISA
Application: WB, ELISA, FC, IHC, IP
Application: SPR, Inhib, FuncS
Application: ELISA
Application: FC, IHC, Cyt, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
