Recombinant Anti-IL22 Eliminating Antibody, pH-Sensitive (VS-0625-YC178)
CAT#: VS-0625-YC178
The anti-IL22 eliminating antibody is an engineered pH-sensitive antibody against human IL22. IL22 is involved in immune pathways and associated with diseases like scleritis and hidradenitis. The antibody has a novel IL22-sweeping activity in vivo, which selectively eliminatesthe soluble IL22 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Not detected
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000127318-IL22
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Specifications
- Host Species
- Human
- Type
- Human IgG1 lambda
- Specificity
- Human IL22
- Species Reactivity
- Human
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1442-sdAb | Recombinant Anti-Human IL22 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-748 | Anti-IL22 Recombinant Antibody (TAB-748) | WB, IP, IF, FuncS, FC, Neut, ELISA | IgG1 - lambda |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-591LC-S(P) | Anti-human IL22 scFv Fragment (266.16.1.4.4.1) | ELISA, FC, IHC | |
| TAB-594LC-S(P) | Anti-human IL22 scFv Fragment (267.4.1.1.4.1) | ELISA, FC, IHC | |
| TAB-595LC-S(P) | Anti-human IL22 scFv Fragment (266.12.6.1.3.2.1) | ELISA, FC, IHC | |
| TAB-596LC-S(P) | Anti-human IL22 scFv Fragment (266.19.1.10.5.2) | ELISA, FC, IHC | |
| TAB-597LC-S(P) | Anti-human IL22 scFv Fragment (267.9.1.1.4.1) | ELISA, FC, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1328CQ | Mouse Anti-IL22 Recombinant Antibody (clone CBL551) | Neut | Mouse IgG1 |
| NEUT-1329CQ | Mouse Anti-IL22 Recombinant Antibody (clone CBL972) | ELISA, Neut | Mouse IgG1 |
| NEUT-1330CQ | Rat Anti-IL22 Recombinant Antibody (clone VC22) | FuncS, Neut | Rat IgG2a, κ |
| NEUT-1331CQ | Rat Anti-Il22 Recombinant Antibody (VMC197) | Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1803 | Rabbit Anti-IL22 Recombinant Antibody (clone DS1803AB) | WB | Rabbit IgG |
| MOR-4614 | Rabbit Anti-IL22 Recombinant Antibody (clone TH127DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0305-YC-S(P) | Human Anti-IL22 Recombinant Antibody; scFv Fragment (HPAB-0305-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-0413-CN-S(P) | Human Anti-IL22 Recombinant Antibody; scFv Fragment (HPAB-0413-CN-S(P)) | ELISA, Block | Human scFv |
| HPAB-0414-CN-S(P) | Human Anti-IL22 Recombinant Antibody; scFv Fragment (HPAB-0414-CN-S(P)) | ELISA, Block | Human scFv |
| HPAB-0416-CN-S(P) | Human Anti-IL22 Recombinant Antibody; scFv Fragment (HPAB-0416-CN-S(P)) | ELISA, Block | Human scFv |
| HPAB-0830-WJ-S(P) | Human Anti-IL22 Recombinant Antibody; scFv Fragment (HPAB-0830-WJ-S(P)) | ELISA, WB | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0413-CN | Human Anti-IL22 Recombinant Antibody (HPAB-0413-CN) | ELISA, Block | Human IgG4, κ |
| HPAB-0414-CN | Human Anti-IL22 Recombinant Antibody (HPAB-0414-CN) | ELISA, Block | Human IgG4, κ |
| HPAB-0416-CN | Human Anti-IL22 Recombinant Antibody (HPAB-0416-CN) | ELISA, Block | Human IgG4, κ |
| HPAB-0830-WJ | Human Anti-IL22 Recombinant Antibody (HPAB-0830-WJ) | FC, IHC | Humanized IgG1, κ |
| HPAB-0831-WJ | Human Anti-IL22 Recombinant Antibody (HPAB-0831-WJ) | WB, FuncS, IHC | Humanized IgG4, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0413-CN-F(E) | Human Anti-IL22 Recombinant Antibody; Fab Fragment (HPAB-0413-CN-F(E)) | ELISA, Block | Human Fab |
| HPAB-0830-WJ-F(E) | Human Anti-IL22 Recombinant Antibody; Fab Fragment (HPAB-0830-WJ-F(E)) | ELISA, WB | Humanized Fab |
| HPAB-0831-WJ-F(E) | Human Anti-IL22 Recombinant Antibody; Fab Fragment (HPAB-0831-WJ-F(E)) | ELISA, WB | Humanized Fab |
| HPAB-0832-WJ-F(E) | Human Anti-IL22 Recombinant Antibody; Fab Fragment (HPAB-0832-WJ-F(E)) | ELISA, WB | Humanized Fab |
| HPAB-0833-WJ-F(E) | Human Anti-IL22 Recombinant Antibody; Fab Fragment (HPAB-0833-WJ-F(E)) | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-748 | Afuco™ Anti-IL22 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-748) | IP, IF, FuncS, FC, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY134 | CytoStream™ Mouse Anti-IL22 Recombinant Antibody (VS-0225-XY134) | FC | Mouse IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY127 | Human Anti-IL22 scFv-Fc Chimera (VS-0425-FY127) | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3513 | Anti-IL22 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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