Rabbit Anti-IMPDH2 Recombinant Antibody (clone R06-1B8) (CAT#: VS3-FY2015)
The R06-1B8 recombinant monoclonal antibody specifically attaches to human IMPDH2. It cross-reacts with mouse, rat. It is suitable for use in a variety of assays, including WB, IHC-F, IHC-P, ICC/IF, IP. We validate the QC result of the antibody using western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100), immunofluorescence (dilution 1/50-1/200), immunoprecipitation (dilution 1/20). This IMPDH2 antibody has been teted positive by western blot analysis of IMPDH2 in 3T3, mouse liver lysates.
Specific Inquiry
WB
Figure 1 Anti-IMPDH2 Antibody (VS3-FY2015) in WB.
The IMPDH2 expression in 3T3, mouse liver lysates were detected using the anti-IMPDH2 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human IMPDH2
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat IMPDH2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R06-1B8
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 56 kDa, while the observed molecular weight stands at 56 kDa.
- Related Disease
- Impdh2 Enzyme Activity, Variation In and Gtp Cyclohydrolase 1-Deficient Dopa-Responsive Dystonia
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunofluorescence: 1/50-1/200
Immunoprecipitation: 1/20
Target
- Alternative Names
- Inosine Monophosphate Dehydrogenase 2
- Gene ID
- 3615
- UniProt ID
- P12268
- Sequence Similarities
- Belongs to the IMPDH/GMPR family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Ubiquitinated leading to its degradation by the proteasome. (P12268-IMDH2_HUMAN)
The N-terminus is blocked. (P12268-IMDH2_HUMAN)
Acetylated by CLOCK in a circadian manner (PubMed:28985504). (P12268-IMDH2_HUMAN)
Ubiquitination at Lys109, Lys124, Lys134, Lys195, Lys208, Lys293, Lys311, Lys349, Lys422, Lys450, Lys455, Lys474, and Lys489 (NX_P12268 [NX_P12268-1])
Modification sites at PhosphoSitePlus (P12268)
Glycosylation from GlyGen (P12268) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_000875.2; NP_001397688.1; NP_001397689.1; NP_001397690.1
- Function
- Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
IgG Antibody Products
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1826 | Rabbit Anti-IMPDH2 Recombinant Antibody (clone DS1826AB) | WB, IHC, ICC, FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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