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    Rabbit Anti-IRF2 Recombinant Antibody (VS3-CJ653) (CAT#: VS3-CJ653)

    This product is a rabbit antibody that recognizes human, and mouse IRF2.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30813/if_selected.jpg
    Figure 2 IF staining of human cell line A-431
    Figure 2 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57327/if_selected.jpg
    Figure 3 IF staining of human cell line U-251 MG
    Figure 3 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32306/924_G8_1_selected.jpg
    Figure 4 IHC staining of human thyroid gland
    Figure 4 IHC staining of human thyroid gland
    (Immunohistochemical staining of human thyroid gland shows strong nuclear positivity in glandular cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30813/ihc_selected.jpg
    Figure 5 IHC staining of human colon
    Figure 5 IHC staining of human colon
    (Immunohistochemical staining of human colon shows strong nuclear positivity in glandular cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32306/66200_A_7_3_selected.jpg
    Normal Tissue
    Figure 6 Cerebral cortex
    Figure 6 Cerebral cortex
    (Glial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear
    Neuropil
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32306/66140_B_7_5.jpg
    Figure 7 Colon
    Figure 7 Colon
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32306/66200_A_7_3.jpg
    Figure 8 Kidney
    Figure 8 Kidney
    (Cells in glomeruli
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Nuclear
    Cells in tubules
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32306/66200_A_7_5.jpg
    Figure 9 Urinary bladder
    Figure 9 Urinary bladder
    (Urothelial cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32306/66200_A_4_5.jpg
    Figure 10 Testis
    Figure 10 Testis
    (Leydig cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Peritubular cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Preleptotene spermatocytes
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Spermatogonia cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32306/66200_A_4_6.jpg
    Figure 11 Lymph node
    Figure 11 Lymph node
    (Non-germinal center cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32306/66200_A_9_8.jpg
    RNA Expression
    Figure 12 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
    Figure 12 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168310-IRF2

    Specifications

    • Immunogen
    • Recombinant protein
    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Human, Mouse IRF2
    • Species Reactivity
    • Human, Mouse
    • Applications
    • WB, ICC, IF
    • Conjugate
    • Unconjugated

    Product Property

    • Purification
    • Protein A affinity purified
    • Purity
    • >95% as determined by SDS-PAGE
    • Format
    • Liquid
    • Buffer
    • 40% Glycerol, 1% BSA, TBS, pH7.4.
    • Preservative
    • 0.05% Sodium Azide
    • Storage
    • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence.

    Target

    • Alternative Names
    • IRF-2
    • Sequence Similarities
    • Belongs to the IRF family.
    • Cellular Localization
    • Nucleus
    • Post Translation Modifications
    • Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
      The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.
    • Function
    • Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

    Recommended Products

    Isotype Control

    Secondary Antibody

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "IRF2"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    IgG Antibody Products Rabbit Monoclonal Antibody Products IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
    CAT Product Name Application Type
    DrMAB-355 Recombinant Human Anti-Human IRF2 Antibody, clone T307 IF, ELISA IgG
    MOB-0995CT Recombinant Mouse anti-Human IRF2 Monoclonal antibody (EML466) ICC/IF, IHC-P, WB
    MRO-0868-CN Recombinant Rabbit Anti-IRF2 Monoclonal Antibody (CBACN-320) WB, IF Rabbit IgG
    VS-0923-FY197 Recombinant Mouse Anti-IRF2 Antibody (VS-0923-FY197) ELISA, WB Mouse IgG1

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